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HOXA10对围着床期子宫内膜接受性的调节

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摘要 同源框基因(HOX)是属于多基因家族的转录调节基因,其重要功能是调节胚胎发育,近年研究表明,HOXA10与胚胎着床密切相关。正常月经周期中,HOXA10在人类子宫腺细胞和基质细胞均有表达,并且在着床窗口期表达增加。母体HOXA10的正常表达是胚胎着床的条件。HOXA10可能通过直接调节整合素β3的表达、调节前列腺素(PG)系统功能及刺激基质细胞增生等机制,调节子宫内膜接受性。HOXA10受卵巢激素和松弛素调节,HB-EGF和LIF对HOXA10的表达也有调节作用。
作者 陈骞 孙海翔 胡娅莉
机构地区 南京大学医学院附属鼓楼医院生殖中心
出处 《现代妇产科进展》 CSCD 北大核心 2005年第3期241-243,共3页 Progress in Obstetrics and Gynecology
关键词 同源框基因 胚胎着床 子宫内膜接受性 综述文献
分类号 R695.1 [医药卫生—泌尿科学]
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参考文献16

  • 1Kim JJ, Fazleabas AT. Uterine receptivity and implantation : The regulation and action of insulin-like growth factor binding protein-1 ( IGFBP-1 ) , HOXA10 and forkhead transcripton factor-1 (FOXO-1) in the baboon endometrium[J]. Reprod Biol Endocrinol,2004,2:34-40.
  • 2李红,陈士岭,邢福祺.HOXA10基因在子宫内膜组织中的表达及与不孕的关系[J].中华妇产科杂志,2002,37(1):30-32. 被引量：21
  • 3Bagot CN, Troy PJ, Taylor HS. Alteration of maternal HOXA10 expression by in vivo gene transfection affects implantation[J]. Gene Ther,2000,7 : 1378 -1384.
  • 4Salih SM,Taylor HS. HOXA10 gene expression in human fallopian tube and ectopic pregnancy[J].Am J Obstet Gynecol,2004,190:1404-1406.
  • 5Cermik D,Karaca M,Taylor HS. HOXA1 expression is repressed by progesterone in the myometrium: differential tissuesecific regulation of HOX gene expression in the reproductive tract [J]. J Clin Endocrinol Metab,2001, 86:3387-3392.
  • 6Cermik D,Selam B,Taylor HS. Regulation of HOXA10 exression by testosterone in vitro and in the endometrium of patients with polycystic ovary syndrome[J].J Clim Endocrionl Metab,2003,88:238-243.
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  • 10Das SK,Lim H,Paria BC, et al.Cyclin D3 in the mouse uterus is associated with decidualization proccss during early prognancy[J].J Mol Endcrinol,1999,22:91-101.

二级参考文献6

  • 1申洪.免疫组织化学染色定量方法研究（Ⅲ）[J].中国组织化学与细胞化学杂志,1995,4(1):89-92. 被引量：398
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  • 5Benson GV, Nguyen TH, Maas RL. The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of abdominal B-like genes. Mol Cell Biol, 1995, 15:1591-1601.
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现代妇产科进展
2005年 第3期

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