花朱顶红中非生物碱类成分研究(英文)

Non-alkaloids in Hippeastrun vittatum

目的研究石蒜科植物花朱顶红中非生物碱类成分。方法采用大孔树脂、硅胶、ODS柱色谱分离纯化,经理化常数、光谱学方法鉴定结构。结果分离得到了5个葡糖鞘脂类成分,其结构分别鉴定为(2S,3R,4E,8Z)-2-[(2R-2-羟基十六酰)氨基]-4,8-十八二烯-1,3-二醇1-O-β-D-吡喃葡萄糖苷()、(2S,3R,4E,8E)-2-[(2R-2-羟基十六酰)氨基]-4,8-十八二烯-1,3-二醇1-O-β-D-吡喃葡萄糖苷()、(2S,3R,4E,8Z)-2-[(2R-2-羟基十八酰)氨基]-4,8-十八二烯-1,3-二醇1-O-β-D-吡喃葡萄糖苷()、(2S,3R,4E,8E)-2-[(2R-2-羟基十八酰)氨基]-4,8-十八二烯-1,3-二醇1-O-β-D-吡喃葡萄糖苷()、(2S,3R,4E,8Z)-2-[(2R-2-羟基二十酰)氨基]-4,8-十八二烯-1,3-二醇1-O-β-D-吡喃葡萄糖苷()。结论它们均为首次从花朱顶红中分得。

Objective To investigate the non-alkaloid constituent of Hippeastrun vittatum(Amaryllidaceae).Methods Solvent extraction and column chromatography were used to isolate the(non-alkaloid) constituents,and physicochemical constants and spectroscopic analysis were employed for structural elucidation.Results Five glycosphingosilipids were isolated,and their structures were elucidated to be(2S,3R,4E,8Z)-2-[(2R-2-hydroxyhexadecanoyl) amido]-4,8-octadecadiene-1,3-diol 1-O-β-D-glucopyranoside(Ⅰ),(2S,3R,4E,8E)-2-[(2R-2-hydroxyhexadecanoyl) amido]-4,8-octadecadiene-1,3-diol 1O-β-D-glucopyranoside(Ⅱ),(2S,3R,4E,8Z)-2-[(2R-2-hydroxyoctadecanoyl) amido]-4,8-octadecadiene-1,3-diol 1-O-β-D-glucopyranoside(Ⅲ),(2S,3R,4E,8E)-2-[(2R-2-hydroxyoctadecanoyl) amido]-4,8-octadecadiene-1,3-diol 1-Oβ-D-glucopyranoside(Ⅳ),(2S,3R,4E,8Z)-2[(2R-2-hydroxyeicosadecanoyl) amido]-4,8-octadecadiene1,3-diol 1-O-β-D-glucopyranoside(Ⅴ),respectively.Conclusion They are all isolated from the fresh bulbs of H.vittatum for the first time.