慢性胃溃疡恶性潜能的探讨——AgNOR定量及粘液组织化学分析

Study of Malignant Potentials in Gastric Ulcer

通过86例胃溃疡(GU)97个病灶及11例GU癌变病灶的组织学观察、粘液组织化学分析及AgNOR定量研究,将GU再生上皮分为四型。结果发现AgNOR定量与组织学、细胞分泌功能有密切关系。GuA型在组织学、粘液性质、AgNOR定量以及GU周边粘膜伴随病变等方面均有别于Gu B、Gu C及Gu D型,确为一种良性溃疡。而Gu D型在各方面均相似于癌性上皮,具有明显的恶性倾向。Gu B及Gu C型中的部分病例具有较大的恶性潜能,有可能癌变,需进一步密切随访和研究。

AgNORs and histochemistry werecarried out in 86 cases of gastric ulcers (GU) and 11 cases of malignant change of GU. The re-genetive epithelia of GU was divided into four types. The results showed that there was an intimate relationship among the AgNORs counts, morphology and secretory function of these cell-s. The GU A type was truly a benign GU which was distinct from GU B, GU C and GU D types in its morphology, mucin property, AgNORs counts and accompanying lesion. While GU D type possessed malignant tendency as they weremore alike cancerous epithelium. Some cases of GU B and GU C types with high AgNORs counts, dysplasia Ⅱ B-IM change were considered to have more malignant potentials. Fol-lowup of these cases may help to clarify its biologic characteristics.