胃肠道粘膜相关淋巴组织原发淋巴瘤病理学研究

Pathological Study of Gastrointestinal Mucosa-associated Lymphoid Tissue-derived Lymphoma

为明确胃肠道原发NHL特别是MALT淋巴瘤的发病特征及组织学起源,本研究使用LN_(1～3)系列抗体对34例胃肠道原发NHL进行免疫组化检测。结果显示:34例中MALT淋巴瘤5例(14.7％),其中3例由滤泡中心细胞样细胞构成,另2例由中心母细胞样细胞构成。肿瘤细胞在LN_1显示核周边点状阳性,LN_2显示核膜线状阳性,与正常肠道Peyet板僧帽带处的Marginal zone cell具有相似的形态及染色特性,提示MALT淋巴瘤可能来源于Marginal zone cells。

In order to characterize the cytologic fetures and histogenes of gastrointestinal (GI) NHL, especially MALT lymphoma, the im-munohistochemical study was performed in 3-1 cases of GI NHL by use of LN1-3 antibodys. The results showed that 5 (14. 7%) out of 34 cases were MALT lymphoma, 3 cases of which were composed of centrocyte-like(CCL) cell and the other 2 were of large blast-like cell. In all cases, the positive finding of paranuclear dot for LN1 and nuclear membrane for LN2. The morphologic and immunohistochemical fetures of MALT lymphoma cells were like marginal zone cells of Peyer's patches of intestine. Based on these findings, a histogenesis of MALT lymphoma was marginal zone cells.