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抑癌基因PTEN和胰岛素样生长因子-1受体在子宫内膜癌中的表达及临床意义 被引量：2

The expression of PTEN gene and insulin-like growth factor-1 receptor in endometrial cancer tissues and its clinical significance
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摘要 目的研究抑癌基因PTEN和胰岛素样生长因子1受体(IGF1R)与子宫内膜癌临床及病理特征的关系。方法应用免疫组织化学方法(SP法)检测45例子宫内膜癌组织中PTEN基因和胰岛素样生长因子1受体的表达。结果45例子宫内膜癌组织中,PTEN阳性表达率为28.89%;Ⅰ期患者和Ⅱ～Ⅲ期患者阳性表达率分别为44.00%和10.00%(P<0.05);在高、中、低分化子宫内膜癌中的阳性表达率分别为60.00%、15.00%和10.00%(P<0.05);无、有淋巴结转移者的阳性表达率分别为38.71%和7.14%(P<0.05);IGF1R阳性表达率为86.67%。结论PTEN基因抑制子宫内膜癌的生长、浸润及淋巴结转移;IGF1R在子宫内膜癌的发生中发挥着重要作用。 Objective To study the expression of PTEN gene and IGF-1R in endometrial cancers and clarify the relationship between the expression and the clinicopathological parameter.Methods The expression of PTEN and IGF-1R in 45 samples of endometrial cancer tissues were detected by immunohistochemical stainings.Results The expression of PTEN in endometrial cancer tissues was 28.89%.The positive rate in clinical cancer stages Ⅰ and Ⅱ～Ⅲ was 44.00% and 10.00%(P<0.05) respectively.The positive rate in the high,middle and low pathohistologic grading was 60.00%,15.00% and 10.00%,respectively(P<0.05).38.71% of the cases without and 7.14% of the cases with node metastasis showed positive for PTEN(P<0.05).The expression of IGF-1R in endometrial cancers tissues was 86.67%.Conclusions PTEN gene may inhibit the growth,invasion and metastasis of endometrial cancer.IGF-1R plays an important role in pathogenesis and development of endometrial cancers.
作者 刘新琼 彭树松 李晖晖 徐洪斌
机构地区 深圳市人民医院妇产科(暨南大学医学院第二附属医院)
出处 《中国基层医药》 CAS 2005年第6期684-685,共2页 Chinese Journal of Primary Medicine and Pharmacy
关键词 抑癌基因 PTEN 胰岛素样生长因子-1受体 子宫内膜癌 表达 Endometrial neoplasms Gene Receptor,IGF type 1
分类号 R737.33 [医药卫生—肿瘤]
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参考文献5

  • 1Risinger JI, Hayes AK. PTEN/MMACI mutations in endometrial cancer. Cancer Res, 1997,57:4736-4738.
  • 2Mutter GL, Lin MC, Fitzgerald JT, et al. Altered PTEN expression as diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst, 2000,92: 924-930.
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同被引文献27

  • 1张俊梅,杨大同,张宏伟,魏丽惠,周蓉,虞有智.胰岛素样生长因子-1受体在子宫内膜癌中的表达及临床意义[J].中国妇产科临床杂志,2005,6(5):359-361. 被引量：6
  • 2[1]Guasch G,Ollendorff V,Borg JP,et al.8p12 stem cell myeloproliferative disorder:the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways[J].Mol Cell Biol,2001,21(23):8129-8142.
  • 3[2]Mano Y,Takahashi K,Ishikawa N,et al.Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer[J].Cancer Sci,2007,98(12):1902-1913.
  • 4[3]Olaussen KA,Soria JC,Morat L,et al.Loss of PTEN expression is not uncommon,but lacks prognostic value in stage I NSCLC[J].Anticancer Res,2003,23(6C):4885-4890.
  • 5[4]Panigrahi AR,Pinder SE,Chan SY,et al.The role of PTEN and its signalling pathways,including AKT,in breast cancer;an assessment of relationships with other prognostic factors and with outcome[J].J Pathol,2004,204(1):93-100.
  • 6[8]Mikolajka A,Yan X,Popowicz GM,et al.Structure of the N-terminal domain of the FOP(FGFR1OP) protein and implications for its dimerization and centrosomal localization[J].J Mol Biol,2006,359(4):863-875.
  • 7[9]Yan X,Habedanck R,Nigg EA.A complex of two centrosomal proteins,CAP350 and FOP,cooperates with EB1 in microtubule anchoring[J].Mol Biol Cell,2006,17(2):634-644.
  • 8[10]Dey N,Crosswell HE,De P,et al.The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration[J].Cancer Res,2008,68(6):1862-1871.
  • 9[11]Koul D,Takada Y,Shen R,et al.PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells[J].Biochem Biophys Res Commun,2006,350(2):463-471.
  • 10[12]Parsa AT,Waldron JS,Panner A,et al.Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma[J].Nat Med,2007,13(1):84-88.

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中国基层医药
2005年 第6期

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