血清CA125检测对卵巢上皮性癌预后的价值

The prognostic value of the serum CA125 detection in patients with epithelial ovarian carcinoma

目的:探讨血清CA125在卵巢上皮性癌中的预后价值。方法:采用回顾性分析方法,对2000年1月～2003年5月中国医科大学附属第一医院妇科收治的60例上皮性卵巢癌患者手术前后血清CA125水平,及其结合病理、分期及预后等临床资料进行分析。结果:术前血清CA125水平与组织类型和临床分期相关(P<0.05),术后CA125半衰期>20d者,复发率高于≤20d者,而复发的中位时间短于≤20d者(P<0.05)。多因素分析表明:临床分期和CA125半衰期对预后有影响。术后CA125水平的升高可预测复发。结论:上皮性卵巢癌患者术前测定血清CA125水平可初步判断组织类型及临床分期,术后监测血清CA125水平可及时发现复发,并可判断预后。

Objective: To discuss the prognostic value of the serum CA125 in patients with epithelial ovarian carcinoma.Methods:60 patients with epithelial ovarian carcinoma underwent operation in this Hospital between January 2000 and May 2003.Correlation analysis among the serum CA125 level and histological type, FIGO stage were carried out retrospectively.Results:The serum CA125 level before operation was related to histological type and FIGO staging(P<0.05). The recurrent rate in patients with half-life >20 days was higher than those ≤20 days.In contrast, the recurrent mean time was shorter than those ≤20 days (P<0.05). Analysis of prognostic multi-factors showed: FIGO stage and estimate the half-life of CA125 were prognostic factors. The increase of the serum CA125 level after operation usually indicated recurrence.Conclusion:The serum CA125 level before operation of epithelial ovarian cancer can help know the histological type and FIGO stage. This marker is useful in the early detection of recurrence and interpretable prognosis.