先天性甲状腺功能减低症的新生儿筛查及临床分析

Screening on neonatal with congenital hypothyroidism and its clinical analysis

目的:总结分析深圳市5年来开展先天性甲状腺功能减低症(CH)新生儿筛查和诊断治疗情况。方法:建立深圳市所有产科医院的筛查网络,以非选择性新生儿为对象,在出生72h后采足跟血,检测滤纸标本中促甲状腺激素(TSH)含量,筛查阳性者,以静脉血血清标本复查TSH,T3、T4确诊。结果:5年共筛查213085人,其中确诊为CH61例,发病率为0.286‰。早期诊断治疗及随访,患儿的智能和体格发育无明显异常。结论:新生儿疾病筛查是CH早期诊断的有效措施之一,采取早期诊断和治疗能有效地防止患儿的智力和体格发育低下。

Objective:The congenital hypothyroidism(CH) neonatal screening,diagnosis and treatment in Shenzhen city were studied.Methods:The neonates were screened on CH at 72 hours after birth by measuring thyroid-stimulating hormone(TSH) of whole blood saturated filter paper disks with enzyme-linked immunoassy.The diagnosis of CH was by serum TSH,T_3,T_4.Results:Of 213 085 neonates screened,61 cases were confirmed to be CH,the incidence was 0.286‰.The significant abnormal in growth and development of them was not seen by early diagnosis and treatment.Conclusion:The neonatal screening is an effective step for early diagnosis of CH.Early diagnosis and treatment could effectively prevent the maldevelopment in intelligence and physique of children with CH.