3种治疗2型糖尿病药物的成本-效果分析

Cost-effectiveness Analysis of 3 Different Drugs in the Treatment of Type 2 Diabetes Mellitus

目的:比较3种治疗2型糖尿病药物的成本-效果。方法:将186例2型糖尿病患者随机分成3组,分别用阿卡波糖(A组)、二甲双胍(B组)和格列齐特(C组)治疗,并进行药物经济学成本-效果分析。结果:A、B、C组成本分别为776.62、345.55、565.28元;对空腹血糖的总有效率分别为85.5%、84.6%、86.4%,对餐后2h血糖的总有效率分别为95.2%、72.3%、77.9%;对空腹血糖的成本-效果比分别为9.08、4.08、6.54元,对餐后2h血糖的成本-效果比分别为8.16、4.78、7.26元;A、C组相对于B组对空腹血糖的增量成本-效果比分别为478.9、122.1元,对餐后2h血糖的增量成本-效果比分别为18.82、39.23元。结论:控制空腹血糖以二甲双胍为佳;控制餐后血糖或以控制餐后血糖为主时以阿卡波糖为佳。

OBJECTIVE:To compare the cost-effectiveness of3different drugs in the treatment of type2diabetes mellitus.METHODS:186 cases with type 2 diabetes mellitus were randomized to 3 groups:Group A was treated with acarbose;Group B was treated with dimethyl biguanide and Group C was treated with gliclazide.The cost-effectiveness of the three groups was analyzed.RESULTS:The costs for Group A,B and C were 776.62 yuan,345.55 yuan and 565.28 yuan respecˉtively;the total effective rates on blood-fasting sugar were 85.5%,84.6% and 86.4% respectively;the total effective rates on blood sugar 2 hours after meal were 95.2%,72.3% and 77.9% respectively;the cost-effectiveness ratio on blood-fasting sugar were 9.08 yuan,4.08 yuan and6.54yuan respectively;the cost-effectiveness ratio on blood sugar 2 hours after meal were 8.16 yuan,4.78 yuan and7.26 yuan respectively;the increments of cost-effectiveness ratios of group A and C on blood-fasting sugar were478.9yuan and122.1yuan respectively as against Group B;the increments of cost-effectiveness ratios of Group A and C on blood sugar 2h after meal were 18.82 yuan and 39.23 yuan respectively as against group B.CONˉCLUSION:It is better to use dimethyl biguanide to control blood-fasting sugar level while it is better to use acarbose to control the level of postprandial blood sugar or take the controlling of postprandial blood sugar as priority.