ACE基因多态性与PTCA合并支架植入术后再狭窄的相关性研究

Relationship between the Polymorphism of Angiotensin I Converting Enzyme Gene and In-stent Restenosis after PTCA with Stent Planting

目的:探讨血管紧张素Ⅱ转换酶(ACE)基因的多态性与PTCA合并支架植入术后发生支架内再狭窄(ISR)的相关性。方法:选取2001-2003年入我院治疗,成功实施PTCA合并支架植入手术的华东地区冠心病患者共197例,并作为期半年的追踪随访,按照二次冠状动脉造影结果分为术后再狭窄组和未狭窄组,然后运用PCR技术对这197例患者样本进行ACE基因分型,最后采用统计学方法判断ACE基因多态性是否与支架内再狭窄具有相关性。结果:197例患者中再狭窄组为58例,ACE基因型DD、DⅠ、Ⅱ的频率分别为25.9%、39.6%、34.5%;未狭窄组为139例,ACE基因型DD、DⅠ、Ⅱ的频率分别为33.8%、43.9%、22.3%,两组间无显著差异(x2=3.2N).P>0.05)。再狭窄组和未狭窄组的D等位基因的频率分别为52.6%和55.8%,亦无显著差异(x2=3.326.P>0.05)。结论:ACE基因1/D多态性与支架术后再狭窄无相关性。

Objective: To explore the relationship between the polymorphism of angiotensin I converting enzyme gene and the incidence of in-stent restenosis(ISR) after PTCA with stem planting. Methods: In this study we selected 197 coronary artery disease patients living in Eastern China, who underwent successful coronary artery stem placement from 2001 to 2003. All the patients were divided into two groups,the ISR group and the NISR group, based on the results of angiography 6 months later,and their polymorphisms were decided by polymerase chain reaction( PCR). then correlation analysis was done between angiotensin polymorphism and in - stent restenosis. Results: The results of angiography turned out to be 58 ISR samples and 139 NISR samples. According to the PCR results,the ACE gene had three Genotypes(DD.DI,and II ), the frequency of them were 25. 9% .39. 6% ,and 34. 5% respectively in the ISR group,and 33. 8%,43. 9% ,and 22. 3% respectively in the NISR group, no significant discrepancy was show between the two groups(x2 = 3. 250,P>(). 05). The frequency of D alete(52. 6%) in the ISR group was also no significant discrepancy compared to D alete(55. 8%) in the NISR group(x2 = 3. 326,P> 0.05). Conclusion: There was no correlation between the I/D polymorphisms of ACE gene and after stenting restenosis.