转移性卵巢癌临床研究分析

Analytical Study of the Ovarian Metastatic Carcinoma

目的探讨转移性卵巢癌疾病的诊断及治疗。方法回顾分析临床及病理明确诊断转移性卵巢癌52例。结果:转移性卵巢癌病人中有腹胀表现为42例(80.77%)、少量至中量腹水38例(73.08%),B超提示卵巢肿瘤直径小于10cm41例(78.85%),CA125小于200U/ml48例(92.31%)及CEA大于10ng/ml共47例(90.38%),CA125/CEA比值介于5-10者共有46例(88.46%)。经过手术及有效化疗5-6疗程的病人31例(59.62%)平均生存期为14.45个月,手术未行化疗及仅化疗3疗程以下的病人21例(40.38%)平均生存期为5.9个月,此两组经LogRank检验(P<0.01)有显著差别。结论:卵巢肿瘤病人,如有腹胀、腹水、B超示卵巢肿瘤直径小于10cm、CA125小于200U/ml及CEA大于10ng/ml、CA125/CEA比值介于5-10,应高度怀疑转移性卵巢癌;并应积极给予手术加有效足够的化疗以延长病人的生存时间。同时还应给予病人心理治疗。

Objective: To study the diagnosis and treatment of the ovarian metastatic carcinoma. Methods: Metastatic ovary carcinoma diagnosed by pathlogy and clinic evidence were analyzed retrospectively. Results: Most metastatic carcinoma in the ovarian appeared the following features: 42 of 52(80. 77%) patients had abdominal distension,38 of 52(73. 08%) patients had a little ascites,41 of 52(78. 85%) patients had the ovary mass' diameter less than 10 cm by ultrasonic scan,48 of 52 patients (92. 31 %) had CA125 less than 200 U/ml and 47 of 52(90. 38%)CEA more than 10 ng/ml ,46 of 52 (88. 46%) patients result showed 5-10 for the CA125/CEA ratio. 31 cases were operated and treated effectively with 5-6 courses chemotherapy, survived for 14. 45 months averagely. 21 cases were operated and treated with less then 3 courses or without chemotherapy.there were great statistically significance in the two groups. Conclusion:The patients with ovary mass are suspected metastatic carcinoma companied by abdominal distension, ascites, less than 10 cm by examined B ultrasonography in diameter, CA125 less than 200 U/ml and CEA more than 10 ng/ml, 5-10 for the CA125/CEA ratio . These patients should be operated and combined effective chemotherapy so as to prolong the patients lifetime, and also psychology treatment for the patients.