摘要
以磷酸作催化剂,γ-丁内酯和苄胺反应合成了1-苄基-2-吡咯烷酮,研究了反应条件对反应的影响,确定了最佳工艺条件:n(γ-丁内酯)∶n(苄胺)∶n(磷酸)=1.0∶1.5∶0.1,反应时间2h,反应温度为180~210℃;产物经减压蒸馏分离提纯,蒸馏后的残余物作催化剂循环使用,1-苄基-2-吡咯烷酮收率为91.6%,质量分数99.3%;产品用元素分析、红外、核磁等进行了确证。
1-Benzyl-2-pyrrolidinone was prepared by the reaction of γ-butyrolactone and benzyla?mine catalyzed by phosphoric acid.Factors influencing the reaction were studied and the optimum process conditions were deter?mined:n(r-butyrolactone):n(benzyla?mine):n(phosphoric acid)=1.0:1.5:0.1,reaction temprature was 180～210?℃ and reaction time 2h.The yield was 91.6% and weight percent of 1-benzyl-2-pyrrolidinone was 99.3%.The product was assignd by elemental analysis,IR and (^(1) H NMR).
出处
《化工科技》
CAS
2005年第3期14-16,共3页
Science & Technology in Chemical Industry
基金
山东省中青年科学家基金资助项目。
