肺泡II型上皮细胞细胞外信号调节激酶激活与急性肺损伤
Extracellular Signal-Regulated Kinase Activation of Alveolar Type II Epithelial Cell in Acute Lung Injury
摘要
肺泡上皮屏障的受损程度与肺损伤轻重和急性肺损伤的预后密切相关,而肺泡II型上皮细胞对维持肺泡上皮的自身稳定有十分重要的作用。细胞外信号调节激酶是参与细胞增殖、分化、死亡等多种生物学行为的重要信号传导调节激酶。急性肺损伤中肺泡II型上皮细胞细胞外信号调节激酶的激活与细胞周期停滞、细胞因子分泌和作用、肺泡上皮的抗损伤修复有一定关系。
出处
《国外医学(儿科学分册)》
2005年第4期196-198,共3页
Foreign Medical Sciences(Section of Pediatrics)
基金
国家自然科学基金资助项目(30370618)。
参考文献24
-
1Ko JC, Wang YT, Yang JL. Dual and opposing roles of ERK in regulating G (1)and S-G(2)/M delays in A549 cells caused by hyperoxia[J] .Exp Cell Res, 2004,297 (2) :472-483.
-
2Azghani AO, Baker JW, Shetty S, et al. Pseudomonas aeruginosa elastase stimulates ERK signaling pathway and enhances IL-8 production by alveolar epithelial cells in culture[J]. Inflamm Res,2002,51 (10) :506-510.
-
3Geiser T, Jarreau PH, Atabai K, et al. Interleukin-1β augments in vitro alveolar epithelial repair[J] .Am J Physiol Lung Cell Mol Physiol,2000,279(6): L1184-1190.
-
4Upadhyay D, Bundesmann M, Panduri V, et al. Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair[J]. Am J Respir Cell Mol Biol,2004,31 (1):107-113.
-
5Whitmarsh AJ, Davis RJ. Transcription factor AP-1 regulation by mitogenactivated protein kinase signal transduction pathways[J] .J Mol Med, 1996,74(10): 589-607.
-
6Ahmad S, Ahmad A, Ghosh M, et al. Extracellular ATP-mediated signaling for survival in hyperoxia-induced oxidative stress[J] .J Biol Chem,2004,279(16): 16317-16325.
-
7Lee YJ,Cho HN,Soh JW,et al. Oxidant stress-induced apoptosis is mediated by ERK1/2 phosphorylation[ J]. Exp Cell Res,2003,291 (1) :251-266.
-
8Asada S,Fukuda K,Nishisaka F,et al. Hydrogen peroxide induces apoptosis of chondrocyte: involvement of calcium ion and extracellular signal-regulated protein kinase[ J]. lnflamm Res,2001,50( 1 ): 19-23.
-
9Moelling K,Schad K,Bosse M,et al. Regulation of Raf-Akt Cross-talk[J] .J Biol Chem,2002,277(34) :31099-31106.
-
10Roper JM, Mazzatti DJ, Watkins RH, et al. In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type Ⅱ epithelial cells[J].Am J Physiol Lung Cell Mol Physiol,2004,286(5) :L1045-1054.
-
1陈楠,陈莹莹,徐和靖,汪洋,朱立,沈岳良.氯化高铁血红素对血管内皮细胞Erk1/2磷酸化的诱导及维持作用研究[J].中国病理生理杂志,2007,23(4):652-655.
-
2桂华珍,罗华,石明隽,肖瑛,郭兵,张国忠.阿魏酸钠抑制高糖诱导系膜细胞表达PAI-1和p38MAPK[J].贵阳医学院学报,2009,34(1):26-29.
-
3田秀君,史娟,乌姗娜,赵高潮,谷俊朝.肿瘤调节性T细胞与肿瘤免疫[J].中华临床医师杂志(电子版),2010,4(11):115-118. 被引量:4
-
4李龙,马海霞,沈红,刘光伟,赵勇,审阅.巨噬细胞抑制性受体及其免疫调节作用[J].现代免疫学,2007,27(6):512-515. 被引量:4
-
5张丽萍,郑秋甫,何昆仑,唐朝枢,曾强,范英鲜.芦沙坦和苯那普利对心肌丝裂素活化蛋白激酶的抑制作用[J].解放军医学杂志,2001,26(7):527-528.
-
6郝亚华.2型糖尿病患者正常糖代谢一级亲属胰岛素抵抗及B细胞功能研究[J].山西医药杂志,2005,34(12):1031-1032. 被引量:1
-
7王晓红,王玉敏.血浆脑钠肽在心力衰竭中的临床应用[J].中国实验诊断学,2008,12(10):1315-1315. 被引量:16
-
8侯振江,张宗英,郭金英.细胞凋亡与心血管疾病[J].心血管康复医学杂志,2001,10(6):559-561.
-
9刘忠,李闪,朱建华,黄朝阳.不同年龄高血压大鼠血管平滑肌中ERK和MKP-1的表达[J].中国病理生理杂志,2006,22(3):468-471. 被引量:8
-
10田新强,许瑞龄,尹蕾.N-乙酰半胱氨酸对脂多糖诱导的小鼠肝MAPK磷酸化的影响[J].中国病理生理杂志,2008,24(8):1565-1569. 被引量:6