c－erbB－2原癌基因产物在软骨肉瘤中的增强表达

Overexpression of c-erbB- 2 proto-oncogene product in chondrosarcomas

ｃ－ｅｒｂＢ－２原癌基因在细胞增殖和分化的调控中起重要作用。用ＡＢＣ酶标法观察４０例软骨肉瘤中ｃ－ｅｒｂＢ－２原癌基因产物（１９０ＫＤ）的增强表达为９０％（３６／４０），而在良性软骨肿瘤为１１％（１／９），在１０例正常软骨中为阴性。这表明ｃ－ｅｒｂＢ－２原癌基因产物在软骨肉瘤诊断中具有重要实用价值。ｃ－ｅｒｂＢ－２阳性分级与软骨肉瘤组织病理学分级呈显著性负相关（Ｐ＜０．０５），组织学分级高分化差的软骨肉瘤，阳性级别低，可作为软骨肉瘤的分化性标志。

he c-erbB-2 proto-oncogene plays an important role in the regulation of cellular proliferation and differentiation. Overexpression of c-erbB-2 proto-oncogene product in 40 cases of chondrosarcomas was investigated using ABC immunoperoxidase method.Overexpression of c-erbB-2 product was pres-ent in 36/40(90%)chondrosarcomas and in 1 /9(11%)benign cartilage tumors. Normal cartilage tis-sue gave negative results.These findings indicate that c-erbB-2 proto-oncogene product has practical value in diagnosing chondrosarcomas.c-erbB-2 positive grading showed a significant inverse correlation with the histopathological grading.Chondrosareomas with high histological grade and poor differentiation showed a bias toward a decline in expression of c-erbB-2 product.The c-erbB-2 proto-oncogenc product may be used as a differentiation marker.