胰腺癌组织中内分泌细胞及其意义研究

The biological significance of endocrine cells in pancreatic carcinoma

４２例胰腺癌嗜银和亲银染色发现１９例４５．２％含内分泌细胞（ＥＣ），其中ＥＣ阳性率≥５０％４例；高分化腺癌ＥＣ阳性率（５／２０例，２５％）低于中、低分化腺癌（１２／１９例，６３．２％）和粘液癌（２／２例，１００％），组织学分级Ⅰ级病例ＥＣ阳性率（５／１８例，２７．８％）低于Ⅲ级病例（７／８例，８７．５％）；ＥＣ阳性病例间质肥大细胞数明显高于ＥＣ阴性病例；发生转移病例ＥＣ阳性率（８／１４例，５７．１％）较高于未转移病例（７／２１例，３３．３％）；１９例ＥＣ阳性病例胃泌素、生长抑素、ＨＣＧ、角蛋白、上皮膜抗原、ＣＥＡ免疫细胞化学阳性分别为８例、４例、５例、１２例、１３例和９例。另外，探讨了胰腺癌组织中ＥＣ的意义、起源和命名等问题。

ndocrine cells(EC) were found in 19 out of 42 cases of the pancreas carcinoma(42.5%).Among them,4 cases had a positive rate of EC more than 50%,The positive rate of EC in the well differentiat-ed carcinomas(5/20)was lower than that of the poorly-differentiated ones(12/19) or mucinous carci-noma(2/2), and the positive rate in histologic grade Ⅰ cases(5/18)was significantly lower than that of the grade Ⅲ cases(7/8 ).The number of mast cells infiltrating in the matrix in EC positive cases was significantly higher than that of the negative ones. The positive rate of EC in the cases with metastasis(8/14)was higher than that of the non-metastasis cases( 7/21).Immunocytochemical staining showed that GN(8),SS(4),HCG(5),CK(12),EMA(13)and CEA(9) were poshive in 19 EC posi-tive cases.