Scid小鼠免疫重建及T、B和NK细胞对CNE－2Z－H_5移植瘤生长的影响

The immune reconstitution in Scid mice and the effect of T,B, NK cells on the growth potential of CNE-2Z-H_5 transplanted tumor

采用近系淋巴细胞输入或移植胸腺重建Ｓｃｉｄ小鼠免疫功能，以环磷酰胺抑制ＢＡＬＢ／Ｃ裸鼠ＮＫ功能，然后移植ＣＮＥ－２Ｚ－Ｈ＿５。移植瘤生长速度及瘤重依次为：Ｓｃｉｄ小鼠组→ＮＫ功能抑制组→ＢＡＬＢ／Ｃ裸鼠组→免疫重建组；淋巴细胞输入组６／６例、胸腺移植组１／３例于荷瘤２２天内移植瘤完全消退。表明免疫重建成功，有较强抗瘤效应。

NE-2Z-H_5 was transplanted into the Scid mice of which immune system was reconstituted with the peripheral lymphocytes or thymus of the isogenetic mice and the BALB/c nude mice of which NK cells were inhibited with cyclophosphamide, The results showed that the growth speed and weight of the tumors were in order from high to low among groups of Scid mice, BALB/c nude mice with NK inhibit-ed,BALB/c nude mice, Scid mice with immune reconstitution. The transplanted tumor,in 6/6 cases injected beforehand with peripheral lymphocytes and 1/3 case transplanted accompanied with thymus disappeared within 22 days. The conclusion is that the imrnune reconstitution of Scid mice has successed and play an effective role in antitumor response.