实验性头外伤后前庭迷路的组织病理变化

Histopatbology of Nonacoustic Labyrinth Following Head Injury in Guinea Pigs

用无依托式头外伤装置，造成豚鼠轻型头外伤模型。痛觉恢复后立即处死６只（Ⅰ组），存活１５天处死５只（Ⅱ组）。颞骨火棉胶包埋，切片光镜观察，见两囊斑病变为大片耳石脱落、斑松解、剥离及感觉上皮空泡化、纤毛区大量球形体。１耳球囊斑脱落耳石靠近连合管。壶腹嵴病变为感觉上皮空泡化，上皮紊乱、松解，纤毛区大量球形体及嵴周嗜碱性颗粒附着。嵴周嗜碱性颗粒附着与嵴顶结石症病理变化一致。表明在头外伤后前庭病变，尤其是两囊斑的损害明显。其继发性病变，如嵴顶结石，连合管堵塞，可能是部分头外伤后听及前庭功能障碍的病理基础。

The histopathological changes in nonacoustic labyrinth induced by experimental head in-jury were studied in 11 guinea pigs. The animals were divided into two groups. The first group were killed after the pain sense recovered and the second group were allowed to survive for 15 days.The tem-poral bones were serially sectioned and observed under light microscope. The pathological findings of the vestibular organs included arragement disturbance,lytic,exfoliate and vacuolization of the sensory ep-ithelia massive spherical bodies in the region of cilium. The otolithic membranes were exfoliated in the utricular and saccular maculae. There was the otolith by the ductus reuniens separated from the saccular maculae in one ear. There were basophilic staining homogenous deposit on the cristae ampullaris.These findings showed that impairments of vestibulae following head injury were obvious.The secondary im-pairments, cupulolithiasis and obstruction of the ductus reuniens, from the utricular and saccular macu-lae were one of the pathologic changes in hearing loss and vertigo following head injury.