期刊文献+

肿瘤坏死因子基因在卵巢肿瘤中的表达 被引量:1

Study on tumor necrosis factor gene cxpressionin ovarian tumor
原文传递
导出
摘要 以地高辛配基标记的肿瘤坏死因子(TNF)-αcDNA为探针,采用原位杂交技术对54例卵巢肿瘤及10例正常卵巢组织新鲜标本制成的冰冻切片,进行肿瘤坏死因子基因检测,观察卵巢肿瘤细胞及肿瘤浸润淋巴细胞(TIL)TNF基因的表达。结果:卵巢癌细胞及TIL的TNF基因阳性率明显高于卵巢大界性和良性肿瘤的瘤细胞及其TIL;临床分期越晚,癌细胞内TNF基因的阳性率越高,而TIL内TNF基因阳性率越低。表明:卵巢肿瘤细胞及TIL内TNF基因水平与其组织学类型及临床分期有关。提示癌细胞TNF基因表达可做为卵巢肿瘤恶性进展的一个标志,TIL的TNF基因表达可做为肿瘤宿主免疫状态受抑制程度的指标。 he tumor necrosis factor ( TNF) gene expressionin ovarian tumor was observed with digoxigeninlabeled TNF-α cDNA probes and in situ hybri-dization technique. 54 cases of fresh biopsies of theovarian tumor and 10 cases of normal ovaries weresnap frozen sectioned. The results showed that the av-erage positive rate of TNF gene expression in someovarian cells and tumor infiltrating lymphocytes ( TIL) was higher than that in the borderline and benign tu-mor cells and TIL. The more advanced clinical stages,the higher does positive rate of TNF gene expressionin the cancer cell and the smaller dose in the TIL. Itwas appeared that TNF gene expression of the tumorcells and TIL was connected with clinical stage and tis-sue typing of ovarian tumor. The data suggested TNFgene expression of cancer cell might play a role in theprogress of ovarian cancer and as a marker of theadvanced malignancy tumors. In addition, TNF geneexprcssion of the TIL might mark the restinced stateof the host immunology.
出处 《中华妇产科杂志》 CAS CSCD 北大核心 1994年第7期389-391,T043,共4页 Chinese Journal of Obstetrics and Gynecology
关键词 肿瘤坏死因子 卵巢肿瘤 基因表达 Tumor necrosis factor Ovariantumor Genes
  • 引文网络
  • 相关文献

参考文献1

  • 1余伟明,癌症,1991年,10卷,12页

同被引文献6

引证文献1

相关主题

;
使用帮助 返回顶部