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免疫竞争饱和法检测血管性痴呆患者血清中糖基化终产物的临床意义

Serum levels of advanced glycosylation end products in patients with vascular dementia
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摘要 目的免疫竞争饱和法检测血管性痴呆患者血清中糖基化终产物(AGEs)含量变化,探讨其在血管性痴呆(VaD)发病机制中的可能作用。方法选取临床诊断为VaD患者35例及47例急性脑血管病(ACVD)患者,采用免疫竞争饱和法测定血清AGEs的水平,同时与健康对照组比较。结果VaD患者AGEs[(14.79±1.76)μgml]明显高于健康对照组[(9.94±1.24)μgml]和ACVD组[(13.13±1.14)μgml],均具显著性差异(P<0.01)。AGEs增高与MMSE评定呈负相关。结论AGEs可能是VaD发病的危险因素。AGEs血清检测可作为血管性痴呆的筛选和诊断依据之一。 Objective To investigate the advanced glycosylation end products in the vascular dementia (VaD) and acute cerebrovascular disease (ACVD). Methods Advanced glycosylation end products (AGEs) was tested by enzyme linked immunosorbent assay (ELISA) in clinical diagnosed 35 cases of VaD and 47 cases of ACVD,and 30 normal people were regarded as control group. Results [WTBZ]The serum AGEs levels in VaD group [(14.79±1.76) μg/ml] were significantly higher than those in ACVD group [(13.13±1.14) ~μg/ml ] and control group [(9.94±1.24) μg/ml] (P<0.01). Conclusion Increased levels of AGEs might be involved in the pathogenesis of VaD.
出处 《医师进修杂志》 2005年第7期19-20,23,共3页 Journal of Postgraduates of Medicine
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