异种PDGF与复方BMP联合使用促进骨缺损的修复

Bone Defect repaired by Using Combined Heterogenic Platelet-derived Growth factor and Bone Morphogenic Protein──An Experimental study

将牛血小板衍生生长因子（ｂＰＤＧＦ）与猪骨形态形成蛋白（ｐＢＭＰ）用于家兔桡骨中段２ｃｍ大段骨缺损的修复。经Ｘ线照片，大体观察、组织学及生物力学检测。术后１４～１８周联合使用ＰＤＧＦ与复方ＢＭＰ组的骨连接率为１００％。实验结果表明：联合应用ＰＤＧＦ和复方ＢＭＰ组的骨连接率及生物力学强度均显著优于单用ＰＤＧＦ或复方ＢＭＰ组。证明ＰＤＧＦ和ＢＭＰ在加快骨缺损的修复方面有协同作用。

AbstractA 2 cm massive segmental radial defects in the rab-bits were repaired by using a combined bovine platelet-derived growth factor(PDGF ) and porcine bone mor-phogenic protein(pBMP).The rate of bone union was100%in samples of 14～18 week after the implantationwith the combined use of bPDGF and pBMP.The induc-tion of new bone formation ,and bone union were found much more satisfactory that seen with either bPDGF orpBMPim planted alone as judged by roengenographic ,macroscopic , microccopic and biomechanical investiga-tions. The results indicated a synergic action of the com-bined use of PDGF and BMP.