加替沙星治疗下呼吸道感染的临床疗效

Clinical Efficacy of Gatifloxaxin in the Treatment of the Low Respiratory Tract Infection

目的:评价加替沙星注射液治疗中、重度下呼吸道感染的有效性和安全性。方法:采用双盲随机对照试验,以左氧氟沙星注射液为对照药。试验组及对照组剂量均为每次200mg,每日2次静脉注射,疗程7d～14d。结果:两组的临床有效率分别为91.4%和85.2%,细菌清除率分别为92.3%和88.2%,不良反应发生率分别是8.6%和11.1%。经统计学分析差异无显著性(P>0.05)。结论:加替沙星为治疗急性下呼吸道感染的有效药物。

Objective To evaluate the efficacy and safety of in the treatment of the low respiratory tract infection.Methods A randomized controlled clinical trial was carried out to compare the clinical efficacy and safety of gatifloxaxin and levofloxaxin. The dose of both gatifloxaxin and ofloxaxin were 200 mg once daily.Both drugs were given by infusion for 7-14 days.Results The clinical efficacy rate of the two groups were 91.4% and 85.2% respectively.The bacterial clearance rates were 92.3% and 88.2% respectively.The adverse events rates were 8.6% and 11.1% respectively . There were no statistical differences between the two groups. Conclusion Gatifloxaxin is useful drug of treating low respiratory tract infection.