逻辑记忆在早期识别阿尔茨海默病患者中的作用

Detecting of Logical Memory Impairment in Mild Alzheimer’s Disease

目的验证逻辑记忆测验在在早期识别AD患者中的作用。方法63例正常对照老人、71例轻度认知功能损害(MCI)与45例轻度阿尔茨海默病(M-AD)患者完成逻辑记忆测验(LM)。结果在正常老人组,LM的即刻回忆、延迟记忆与被试年龄、性别没有显著的相关性(P>0.05),与教育程度有显著相关性(r=0.28,P<0.05)。LM即刻回忆与延迟记忆的相关系数为0.86(P<0.01)。LM即刻回忆与Rey-Osterrich复杂图形记忆测验的延迟回忆、听觉词语记忆测验的相关性比LM延迟回忆的低。LM延迟记忆而不是即刻回忆得分有助于识别MCI。LM即刻回忆≤6分作为划界分,识别AD的敏感性为79%,特异性为87%。LM延迟记忆≤5分作为划界分,敏感性为91%,特异性为89%。结论LM的延迟记忆比即刻记忆更有助于识别轻度认知功能损害与轻度阿尔茨海默病。

Objective To analyze the characteristics of logical memory impairment among mild Alzheimer’s Disease (AD) and amnetic Mild Cognitive Impairment (MCI) and cognitively normal persons.Methods Logical Memory Test was performed in 63 normal controls, and 71 patients with mild MCI and 45 patients with mild AD.Results Scores of immediate recall and delay recall were found to have significant dependability on education in normal elderly group. Delayed recall rather than immediate recall was help to identify MCI subjects. As compared to the LM delay recall, LM immediate recall showed a less correlation between LM and Rey-Osterrich complex figure test and auditory verbal memory test. As a method of diagnosis for mild AD, 79% sensitivity and 87%specificity were performed when scores immediate recall≤6, 91% sensitivity and 89%specificity were performed when scores delay recall≤5.Conclusions Delayed recall rather than immediate recall was help effectively to identify MCI subjects and patients with mild AD.