艾滋病与神经系统机会性感染

Acquired Immunodeficiency Syndrome and Nerve System Opportunity Infection

目的探讨艾滋病(AIDS)合并神经系统(NS)机会性感染的临床特征。方法报道6例人类免疫缺陷病毒(HIV)抗体阳性患者并发NS机会性感染的临床资料,结合文献复习研究AIDS与NS机会性感染的相关性。结果6例分别表现为进行性多灶性白质脑病(PML)、带状疱疹、结核性脑膜炎(2例)、结核性脑、脊髓膜炎和脑脓肿,考虑AIDS所致NS机会性感染。6例患者中5例预后不良。结论HIV具有亲淋巴性的特点,可造成机体严重的细胞免疫缺陷和体液免疫缺陷,较易并发NS机会性感染,且多数预后不良。对NS感染久治无效时,应考虑AIDS可能。

Objective To investigate the clinical features of the acquired immunodeficiency syndrome(AIDS)combined with nerve system(NS) opportunity infection. Methods Clinical data of 6 patients whose serum human immunodeficiency virus(HIV) antibody was positive reaction suffering from AIDS combined with NS opportunity infection were reported, and relativity of AIDS and NS opportunity infection was studied by reviewing literature.Results 6 cases were progressive multifocal leukoencephalopathy (PML, one case), herpes zoster neuralgia (one case)、tuberculous meningitis(2 cases), tuberculous meningitis and spinal arachnoiditis(one case), and intracerebral abscess(one case) respectively and considered NS opportunity infection caused by AIDS. Five of 6 cases had bad prognosis.Conclusions HIV possesses the tendentiousness of being close to lymph system,and resulted in severe immunodeficiency of body cellular immunity and humoral immunity, and made possibility of NS opportunity infection increase obviously. Of all cases, the aftermath of majority was fearful. If the treatment was of no effect to NS infection for a long time in clinical practice, we may consider the possibility of AIDS.