抗单疱病毒单克隆抗体治疗实验性单疱角膜炎的临床与电镜观察

In vivo observations and electron microscopy of thetreatment of cxperimental HSV Keratitis withmonoclonal antibodies

采用抗单纯疱疹病毒（ＨＳＶ）糖蛋白单克隆抗体滴眼治疗实验性单疱角膜炎，其临床疗效与电镜观察结果提示，角膜组织的病理损害明显减轻，并可抑制病毒向周围细胞扩散和缩小病灶范围，起到一定的保护易感细胞的作用。抗ＨＳＶ单克隆抗体作为一种新型生物制剂，为治疗单疱角膜炎开辟了一条新途径。

AbstractIn vivo observations and electron microscopyshowed that topical use of anti-HSV monoclonalglycoprotein antibodies produce.marked antiviral ef-fects in inhibiting the development of experimentalherpetic keratitis in rabbits and in protecting the sus-ceptible corneal cells.As a new biological product,theanti-HSV monoclonal antibodies may provide a newapproach to the treatment of HSV keratitis.