二胺氧化酶在乳腺癌与乳腺腺病组织中的免疫组化研究

IMMUNOHISTOCHEMICAL STUDY ON DIAMINE OXIDASE IN MAMMARY CANCER AND ADENOSIS

近年来国外研究发现，恶性肿瘤患者血液与肿瘤组织中二胺氧化酶（ＤＡＯ）含量明显增高。作者运用免疫组织化学方法研究乳腺癌、乳腺腺病和正常乳腺组织中ＤＡＯ的含量与分布。结果表明，乳腺恶性肿瘤与增生性病变都会引起ＤＡＯ增多，增生越明显，恶性程度越高，ＤＡＯ阳性与含量的增加越显著。用免疫组织化学方法显示ＤＡＯ的含量与分布情况，可以做为估价乳腺组织增生和恶性生长状态的一种标志，对研究乳腺癌的诊断和预后可能有参考意义。

Abstract In recent years, an obvious insrease of diamine oxidase (DAO)in both blood and rumor tissueshas been reported In this assay we observed an increased content and distribution of DAO in mammarycancer and adenosis by immunohistochemistry. The results show that:1. DAO staining was stronglypositive in mammary cancer and the brownish granules were spread over the cytoplasm; 2.In theadenosis of mammary gland, DAO was positive or weakly positive, but those hyperplastic ducts init appeared to be strongly positive and the brownish granules distributed spottedly: 3.The normalmammary tissue presented weak positive or negative DAO reaction. These observations indicatedthat the malignant tumor and hyperplastic changes of mammary gland induce increase of DAO in the cells,and the higher the DAO content,the greater the possibility of malignant changes.