急性白血病患者血清粒细胞-巨噬细胞集落刺激因子和转化生长因子β_1水平测定的临床意义

Clinical significance of GM-CSF and TGF-β_1 levels in serum of patients with acute leukemia

目的探讨粒细胞-巨噬细胞集落刺激因子(GM-CSF)和转化生长因子β1(TGF-β1)水平在急性白血病中变化的临床意义。方法采用酶联免疫法(ELISA)测定96例急性白血病患者血清中GM-CSF和TGF-β1水平。结果急性白血病初诊患者GM-CSF水平明显高于正常对照组(P<0.05),TGF-β1水平明显低于正常对照组(P<0.05)。直线相关分析表明,GM-CSF水平与TGF-β1呈负相关。完全缓解期GM-CSF、TGF-β1水平恢复正常,未缓解和复发患者GM-CSF及TGF-β1水平与初诊患者无明显差异(P>0.05)。结论检测GM-CSF、TGF-β1水平变化有助于急性白血病病情判断,可作为病情判断和疗效观察的辅助指标。

Objective To investigate prognostic significance of granulocyte-macrophage colonystimulating factor (GM-CSF) and transfroming growth factorβ1(TGF-β1) levels in patients with acute leu-kemia (AL).Method ELISA assay were employed to investigate the levels of GM-CSF and TGF-β1in96 AL patients.Results The levels of TGF-β1were much lower at the time of diagnosis than that of nor-mal controls(P<0.05),The levels of GM-CSF were much higher at the time of diagnosis than that of nor-mal controls(P<0.05),Line correlation analysis:GM-CSF correlated negatively with TGF-β1.The levelsof GM-CSF and TGF-β1returned to normal levels in those who got completely remission (CR).There wasno difference among non-remission(NR),relapsed and de novo patients.Conclusion Monitoring the lev-els of GM-CSF and TGF-β1may have prognostic value in clinical outcome and is useful marker treatmentof AL patients.