系统性红斑狼疮患者血清性激素水平的研究

Analysis on serum levels of sex hormones in patients of systemic lupus erythematosus

目的探讨性激素在系统性红斑狼疮(SLE)发病及病程中的作用。方法测定33例SLE患者血清雌二醇(E2)、孕酮(P)、睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)、泌乳素(PRL)的水平。对照组采用年龄、性别和卵巢周期与病例组1:1配对的原则。结果SLE整体组及活动组,PRL均显著升高(P<0.01),LH与T均显著降低(P<0.01)。FSH与LH,LH与PRL存在高度相关性(P<0.01或0.05)。FSH和T对SLE活动性评分的价值最大。结论SLE患者血清中LH与T降低与病情活动有关;对SLE活动评分最有价值的性激素为FSH和T。

Objective The aim of this study is to clarity the serum sex hormones levels of SLE eliminating the influence,and to analyse the role of sex hormones in the episode and progress of SLE.MethodsThe concentration of E_2,P,T,LH,FSH and PRL was monitored in sera from 33 lupus patients and 33 controls.We estimated LACC of SLE,investigated the serum levels of sex hormones by two -related -samples nonparametric tests.Results33 lupus patients and 22 active patients have increased serum PRL levels and reduced serum LH and T levels compared to normal controls(P< 0.01).It is also found that LH levels was positively correlated with the levels of FSH and PRL(P<0.01 or 0.05).Multi-linear regression showed that FSH and T correlate with activity score.ConclusionsThe low serum levels of LH and T are associated with activity of SLE,the most valuble sex homones to activity score are FSH and T.