1[1]Furukawa T, Yamakawa T. Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in xenopusoocytes. J Pharmacol Exp Ther, 1999,291 ( 2 ): 464
2[2]Karasawa A, Kubo K, Oka T, et al. Antihypertensive effects of intravenous administration of benidipine hydrochloride and some other calcium antagonists in conscious spontaneously hypertensive rats. Arzneimittel Forschung, 1988,38 (ⅡA): 1691
3[3]Moriyama T, Karasawa A . Cardiovascular effects of beinidipine and amlodipine in isolated tissues and anesthetized dogs. Biol Pharm Bull,1994, 17(Ⅱ) :1468
4[4]Karasawa A, Nomura H, Nito M, et al. Effect of benidipine hydrochloride (Coniel)on blood pressure, heart rate and plasma norepinephrine concentration in spontaneously hypertensive rats. Japanese journal of pharmacology, 1999,113 ( 5 ) :317
5[5]Kitakaze M, Node K, Minamino T, et al. A Ca channel blocker,benidipine,increases coronary blood flow and attenuates the severity of myocardial ischema via NO - dependent mechanisms in dogs. J Am Coll Cardiol, 1999,33 (1) :242
6[6]Karasawa A, Kubo K, Shuto K, et al. Beneficial effects of the new calcium antagonist benidipine hydrochloride on myocardial dysfunction following cornary occlusion and reperfusion in anesthetized dogs. Arzneimittel Forschung, 1988,38 (ⅡA): 1717
7[7]Kawata T, Hashimoto S, Koike T. Diversity in the renal hemodynamic effects of dihydropyridine calcium blockers in spontaneously hypertensive rats. J Cardiovasc Pharmacol, 1997,30 (4) :431
8[9]Higo K, Karasawa A, Kubo K. Protective effects of benidipine hydrochloride ( KW - 3049 ), a calcium antagonist experimental arterial calcinosis and endothelial dysfunction in rats. J Pharmacobiodyn, 1992,15 ( 3 ): 113
9[10]Nakajima O,Akioka H, Miyazaki M. Effect of the calcium antagonist benidipine hydrochloride on 24 - h ambolatory blood pressure in patients with mild to moderate hypertension ina doubleblind study against placebo. Arzneimittel Forschung, 2000,50(7) :620
1Nakajima O, Akioka H, Miyazaki M. Effect of the Calcium Antagonist Benidipine Hydrochloride on 24- h Ambulatory Blood Pressure in Patients with Mild to Moderate Hypertension in a Double - Blind Study against Placebo. Arzneimittelforschung, 2000;50(7):620
2Muneta S, Kohara K, Hiwada K. Effects of benidipine hydrochloride on 24 - hour blood pressure and blood pressure response to mental stress in elderly patients with essential hypertension. Int J Clin Pharmacol Ther,1999;37(3): 141 ~ 147
3TOHMS Investigation group. The Treatment of Mild Hypertension Study:A Randomized, Placebo - Controlled Trial of a Nutritional - Hygienic Regimen along with Various Drug Monotherapies. Arch Intern Med,1991,151: 1413 ~ 1423
4Proposed guideline for the clinical evaluation of antihypertensive drug products(Draft) .Rockville, MD: FDA Division of Cardio-renal Drug Products: 1988: 4
5Miki S. Effect of Benidipine Hydrochloride, a Ca Antagonist, on Ambulatory Blood Pressure in Patients with Essential Hypertension The Clinical Report, 1993;27:4381 - 4386
6Kalke S, Shah BV, Nair KG, et al. Clinical trial of benidipine in mild to moderate hypertension. J Assoc Physicians India, 1999;47(2): 195- 1977
7Ishii A, Nishida K, Oka T. Receptor Binding Properties of the New Calcium Antagonist Benidipine Hydrochloride. Arazneim. - Forsch,1988;38:1677 - 1680
8Yasuaki D, Masayoshi K, Koichi S. Benidipine Improves Endothelial Function in Renal Resistance Arteries of Hypertensive Rats. Hypertension, 1996;28:58 - 63
9Suzuki M, Kanazawa A, Hasegawa M, Harano Y. Improvement of insulin resistance in essential hypertension by long- acting Ca antagonist benidipine. Clin Exp Hypertens, 1999;21(8): 1327 - 1344
10Yao K, Sato H, Sonoda R. Effects of benidipine and candesartan on kidney and vascular function in hypertensive Dahl rats. Hypertens Res,2003; 26(7) :569- 576
8Suzuki H, Ono E, Ueno H, et al. Physicochemical properties and stability of the highly potent calcium antagonist benidipine hydrochloride[J]. Arzneim Forsch, 1988, 38 (11A): 1 671.
9Yao K,Sato H,Sonoda R,et al. Effects of benidipine and candesartan on kidney and vascular function in hypertensive dahl rats [J].Hypertens Res ,2003,26(7): 569-576.