摘要
目的探讨绒毛膜促性腺激素β亚单位(β-hCG)在子宫颈癌患者病变组织的表达。方法本实验共研究通过活检或刮除术收集的不同临床分期的92例子宫颈癌标本,其中79例为鳞癌,11例为腺瘤,2例原位癌,通过免疫过氧化酶实验技术应用β-hCG抗体,检测相应抗原在宫颈癌石蜡包埋切片中的表达。结果77%(69/90)的宫颈癌患者βhCG抗体表达为阳性,鳞癌阳性例数80%(63/79)明显多于腺癌55%(6/11),β-hCG抗体在宫颈癌晚期患者表达阳性率明显高于早期患者(71%和29%)。结论产生β-hCG的肿瘤预后较差。
Objective This study was designed to investigate the significance of expression of β-hCG in cervical carcinoma. Methods Cervical tissue samples (biopsy /curettage specimens) were collected from 92 patients with either squamous cell or adeno-carcinoma at different stages. Beta-hCG of the samples was examined by immunoperoxidase assay. Results A total of 76% of the cervical carcinoma specimens presented positive signals of β-hCG. The positive rate of squamous cell carcinoma (80%) was higher than adeno-carcinoma (54%). More patients with advanced stages (71%) showed positive staining of β-hCG than patient with early stages (29%). Conclusion Beta-hCG may be correlated to poor prognosis in cervical carcinoma and may serve as a prospective tumor marker.
出处
《中国妇产科临床杂志》
2005年第4期281-283,i001,共4页
Chinese Journal of Clinical Obstetrics and Gynecology
