^(99)TC^m-TRODAT-1 SPECT脑多巴胺转运体显像在帕金森病病情监测中的价值

Clinical application of ^(99)TC^m-TRODAT-1 SPECT imaging of dopamine transporter in monitoring the state of Parkinson’s disease

为了探讨99TCm-TRODAT-1SPECT脑多巴胺转运体(Dopaminetransporter,DAT)显像在帕金森病病情监测中的价值,本研究对20例帕金森病(PD)患者组、14例正常组分别行99TCm-TRODAT-1SPECTDAT显像,利用感兴趣区(Regionofinterest,ROI)技术计算双侧纹状体与小脑的特异性放射性比值(ST/CB)及两侧纹状体特异性放射性摄取比值的不对称指数(AIPD、AICON),同时对PD患者进行UPDRS评分,以及改良Hoehn-Yahr法分级。结果显示PD患者双侧ST/CB均值与病情Hoehn-Yahr分级、UPDRS日常生活能力、运动功能评分呈显著负相关,AIPD与PD病程呈正相关;PD患者与正常对照组的不对称指数有显著性差异,前者高,后者低。因此,99TCm-TRODAT-1SPECT脑DAT功能显像能够监测PD的病情,反映PD病情的严重程度。

To discuss the applicability of 99TCm-TRODAT-1 SPECT imaging of dopamine transporter in monitoring the state of Parkinson's disease (PD), 20 patients with PD and a control group of 14 healthy subjects were chosen to conduct dopamine transporter (DAT) imaging by SPECT with 99TCm-TRODAT-1. The radioactive ratio between bilateral striatum and cerebellum and the asymmetry index (AI) of bilateral striatum were computed by using the region of interest (ROI) technology. Meanwhile, the PD patients were classified by the improved Hoehn-Yahr Disability Score and then evaluated by Unified Parkinson's Disease Rating Scale (UPDRS). The findings show that there is a negative correlation between the bilateral ST/CB mean of the PD and the Hoehn-Yahr grading of the patients' state of illness, the UPDRS score, the patients' self-caring ability, the ability to move around. As for the asymmetry index AIPD, there was a positive correlation with the duration of disease, and a significant difference between the PD and the control group, with the former much higher than the latter. Therefore, the dopamine transporter imaging by SPECT with 99TCm-TRODAT-1 can monitor the state of Parkinson's disease, and show the symptom severity of Parkinson's disease.