复合同种异体颗粒骨修复兔桡骨缺损实验研究

Experimental study on repairing bone defect with the compound of the allogeneic morselized bone

目的观察复合磷酸钙骨水泥同种异体微小颗粒骨修复骨缺损的效果。方法建立兔双侧桡骨中段12mm骨缺损模型,40只兔随机分为A、B、C3组,A组植入复合磷酸钙骨水泥同种异体微小颗粒骨,B组植入同种异体微小颗粒骨,C组为空白对照组。术后4周和8周分别行X线摄片、组织学观察、骨缺损修复血管化观察和生物力学测定。结果A组的骨缺损修复效果、新生骨的组织学结构和生物力学测定均优于B组,C组无骨愈合迹象。结论同种异体微小颗粒骨能较好地修复骨缺损,但复合磷酸钙骨水泥同种异体微小颗粒骨修复骨缺损的效果更佳。

ObjectiveTo observe the effect of the compound of the allogeneic morselized bone and the calcium phosphate cement on repairing bone defect.MethodsThe rabbit models of bilateral radius bone defect were created. 40 rabbits were randomly divided into group A, group B and group C. Animals of the group A were implanted with the compound of the allogeneic morselized bone and the calcium phosphate cement, group B implanted with allogeneic morselized bone, and group C as blank control implanted nothing. The X-ray examination, histopatholgical examination, vascularization and biomechanics of bone defect were evaluated at 4 and 8 weeks after operation.ResultsThe repair of bone defect, quantity and rate of the new formation bone and biomechanics measurement of the group A were superior than the group B; while, no repair of bone defect was found in the group C.ConclusionThe implantation of the allogeneic morselized bone can repair bone defect, but the effect of implanting the compound of the allogeneic morselized bone and the calcium phosphate cement is better than the former.