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心房颤动患者超速激活延迟整流性钾电流重构的研究 被引量：1

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摘要 目的:探讨心房颤动(房颤)患者超速激活延迟整流性钾电流(ⅠKur)的改变及意义。方法:采用膜片钳全细胞法分别记录窦性心律(窦律)患者心房肌细胞(窦律组)和房颤患者心房肌细胞(房颤组)ⅠKur密度,并进行对比。结果:指令电位+20～+50mV时,房颤组ⅠKur密度均较窦律组明显降低(P<0.05)。结论:ⅠKur密度下调是房颤心房电生理重构的重要离子基础,可能对心房动作电位时程的缩短具有一定代偿意义。
作者 陈纯波 吴书林
机构地区 广东省心血管病研究所心内科
出处 《实用医学杂志》 CAS 2005年第13期1414-1415,共2页 The Journal of Practical Medicine
基金 本课题为广东省自然科学基金资助项目(编号:04000526)
关键词 整流性钾电流 心房颤动患者 延迟 激活 膜片钳全细胞法 心房电生理重构 心房肌细胞 动作电位时程 房颤患者 窦性心律 离子基础 密度 窦律
分类号 R541.7 [医药卫生—心血管疾病]
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参考文献13

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二级参考文献11

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共引文献38

同被引文献21

  • 1薛玉梅,吴书林,邓春玉,钱卫民,林秋雄,陈纯波.心房颤动患者内向整流性钾电流及Kir2.1mRNA表达水平的研究[J].中国病理生理杂志,2005,21(4):707-710. 被引量：6
  • 2吴家斌,许春萱,张建成,陈林,林立芳,胡锡衷.心房颤动患者氯电流相关通道CIC-3基因表达的研究[J].中国临床药理学与治疗学,2005,10(6):651-654. 被引量：6
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实用医学杂志
2005年 第13期

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