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主动载药法制备两亲性药物脂质体的研究进展 被引量：28

Progress of Remote Loading of Amphipathic Drugs into Liposomes
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摘要 脂质体跨膜梯度主动载药方法主要有pH梯度法和硫酸铵梯度法。本文介绍了两亲性药物脂质体跨膜梯度载药方法的原理、制备工艺、影响包封率的因素等国内外研究进展。 Remote loading methods of amphipathic drugs into liposomes include pH gradient method and ammo-nium sulfate gradient method. The principles, preparation, influence factors and the progress of this field in both domesticand abroad are introduced.
作者 苗彩云 邓树海 李艳辉
机构地区 山东大学药学院药物制剂研究所
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2005年第7期433-437,共5页 Chinese Journal of Pharmaceuticals
关键词 脂质体 主动载药 PH梯度法 硫酸铵梯度法 综述 liposomes remote loading pH gradient method transmembrane ammonium sulfate gradient method review
分类号 R944.9 [医药卫生—药剂学]
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参考文献28

  • 1Ceh B, Lasic DD. Kinetics of accumulation of molecules into liposomes [J]. J Phys Chem B, 1998, 102 (6): 3036-3042.
  • 2Ceh B, Lasic DD. A rigorous theory of remote loading of drugs into liposomes: transmembrane potential and induced pH-gradient loading and leakage of liposomes [J]. J Colloid Interface Sci, 1997, 185 (1): 9-18.
  • 3Takeuchi H, Kojima H, Toyoda T, et al. Prolonged circulation time of doxorubicin-loaded liposomes coated with a modified polyvinyl alcohol after intravenous injection in rats [J]. Eur JPharm Biopharm, 1999, 48(2): 123-129.
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  • 5Dos Santos ND, Cox KA, McKenzie CA, et al. pH Gradient loading of anthracyclines into cholesterol-free liposomes:enhancing drug loading rates through use of ethanol [J].Biochim Biophys Acta, 2004, 1661 (1): 47-60.
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  • 9Clerc S, Barenholz Y. A quantitative model for using acridine orange as a transmembrane pH gradient probe [J]. Anal Biochem, 1998, 259(1): 104-111.
  • 10Mayer LD, Tai LCL, Ko DSC, et al. Influence of vesicle size,lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice [J]. Cancer Res,1989, 49 (21): 5922-5930.

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共引文献82

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引证文献28

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中国医药工业杂志
2005年 第7期

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