高聚金葡液对非小细胞肺癌化疗患者的骨髓保护及免疫调节作用

Study of Highly Agglutinative Staphylococcin on Protectection of Bonemarrow and Regulation of Immune Function of Patients Receiving Chemotherapy

目的:探讨高聚金葡液对非小细胞肺癌(NSCLC)化疗患者外周血白细胞的保护作用及对免疫功能的调节作用。方法:89例NSCLC化疗患者随机分为单纯化疗组(单化组)和化疗加高聚金葡液组(高化组),分别检测不同时间外周血象和T淋巴细胞亚群变化情况。结果:化疗后,单化组外周血白细胞及CD3+,CD4+,CD4+和CD8+下降非常显著(P<0.01),高化组外周血白细胞下降不明显,而CD3+,CD4+,CD4+/CD8+则有明显升高(P<0.05)。结论:高聚金葡液对NSCLC化疗患者外周血白细胞下降具有明显的保护作用,同时可增强肿瘤患者体液免疫功能。

Objective:To explore the effects of highly agglutinative staphylococcin (HAS) on immune functions and peripheral blood of non-small-cell lung cancer (NS CLC) patients receiving chemotherapy.Methods:Eighty-nine cases of advanced lung cancer were randomly divided into two groups(single chemotherapy group and chemo therapy plus HAS group).The peripheral blood and T lymphocytes subgroup were det ermined respectively.Results:The peripheral blood and CD3+,CD4+,CD4+/CD8+ of sin gle chemotherapy group were significantly decreased,while peripheral blood of ch emotherapy plus HAS group decreased lower than single chemotherapy group,and CD3 +,CD4+,CD4+/CD8+ were significantly increased.Conclusion:There was significant e ffects of highly agglutinative staphylococcin on immune functions and peripheral blood of NSCLC patients receiving chemotherapy.