期刊文献+

甲氧雌二醇抗肿瘤作用研究进展

下载PDF
导出
摘要 目的:对甲氧雌二醇的抗癌作用机理及其应用进行综述。方法:查阅大量文献资料,分类总结。结果:甲氧雌二醇具有抗血管生成、抑制实体瘤生长并促进其凋亡等作用,对多发性骨髓瘤、肉瘤等多种肿瘤均有抗肿瘤活性。结论:甲氧雌二醇是小分子的血管生成抑制剂,具有抗血管生成和抗肿瘤作用,是有发展潜力的抗肿瘤药物。
作者 翁毅力
出处 《中国药业》 CAS 2005年第7期87-88,共2页 China Pharmaceuticals
  • 相关文献

参考文献20

  • 1Fotsis T, Zhang Y, Pepper MS et al. The endogenous oestrogen metabolite 2 - methoxyoestradiol inhibits angiogenesis and suppresses tumour growth [J ]. Nature, 1994, 368 (6 468 ): 237 -239.
  • 2Mooberry SL. Mechanism of action of 2 -methoxyestradiol: new developments[J]. Drug Resist Updat, 2003, 6(6): 355 - 361.
  • 3Shang W, Konidari I, Schomberg DW. 2 - Methoxyestradiol, an endogenous estradiol metabolite, differentially inhibits granulosa and endothelial cell mitosis: a potential follicular antiangiogenic regulator [ J ]. Biol Reprod, 2001,65 (2): 622 - 627.
  • 4Mabjeesh NJ, Escuin D, La Vallee TM, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF [ J ]. Cancer Cell, 2003, 3 (4): 363 - 375.
  • 5Mooberry SL. New insights into 2 - methoxyestradiol, a promising antiangio ~genic and antitumor agent[J]. Curr Opin Oncol, 2003, 15 (6): 425 - 430.
  • 6Brueggemeier RW, Bhat AS, Lovely CJ, et al. 2 - Methoxymethylestradiol: a new 2 - methoxy estrogen analog that exhibits antiproliferative activity and alters tubulinynamlics [ J ]. J Steroid Biochem Mol B iol, 2001,78 (2): 145 -156.
  • 7Klaube N, Parangi S, Flynn Eee, et al. Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2 - methoxyestradiol and taxol [ J ]. Cancer Res, 1997, 57 ( 1 ): 81 - 86.
  • 8Cushman M, Mohanakrishnan AK, Hollingshead M, et al. The effect of exchanging various substituents at the 2 - position of 2 - methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization[J]. J Med Chem, 2002, 45 (21): 4 748 -4 754.
  • 9Wang Z, Yang D, Mohanakrishnan AK, Fanwick PE et al. Synthesis of Bring homalogated estradiol analyogues that modulate tubulin polymerization and microtubule stability [J]. J Med Chem, 2000, 43(12): 2419 - 2249.
  • 10Tinley TL, Leal RM, Randall Hlubek DA, et al. Novel 2 - methoxyestradiol analogues with antitumor activity [ J ]. Cancer Res, 2003, 63 (7): 1538 -1549.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部