短期胰岛素泵治疗对2型糖尿病胰岛β细胞功能的影响

Effect of short-term continuous subcutaneous insulin infusion treatment on beta-cell function in type 2 diabetic patients

目的:探讨短期胰岛素泵(CsII)治疗对伴明显高血糖的2型糖尿病患者的降糖效果和胰岛β细胞功能的影响.方法:对26例空腹血糖≥11.1 mmol/L、餐后2 h血糖≥16.8 mmol/L的2型糖尿病患者进行为期2～4周的胰岛素泵(CSII)治疗,于治疗前后进行馒头餐试验,分析比较治疗前后空腹及餐后2 h血糖、胰岛素原、胰岛素及C肽和由Homa模型计算的Homaβ.结果:短期的CSII治疗显示出快速稳定的降血糖效果,所有患者的血糖均于(4.0±2.0)d达到良好控制,且未出现明显低血糖.胰岛素、C肽水平和Homaβ治疗后显著增加,而胰岛素原水平、胰岛素原和胰岛素的比值较治疗前明显下降.结论:对伴明显高血糖的2型糖尿病患者,短期CSII治疗具有快速降血糖和显著改善胰岛β细胞功能的作用.

Aim: To study the effect of short GAAB2 term continuous subcutaneous insulin infusion(CSII) treatment on beta-cell function in type 2 diabetic patients with severe hyperglycemia. Methods: Twenty-six type 2 diabetic patients with fasting plasma glucose (FPG) ≥11.1 mmol/L and 2 hours postprandial glucose (2hPG)≥16.8 mmol/L were treated by CSII for 2～4 weeks . Oral glucose tolerance test was performed before and after treatment.FPG,2h PG, proinsulin(PI), insulin(INS), C peptide and Homaβ were assayed. Results: The excellent control of FPG and 2h PG was achieved within 4.0±2.0 days. After 2～4 weeks treatment, beta-cell function was dramatically improved: the levels of INS, C peptide,and Homaβ were significantly increased; the levels of PI and PI/INS ratio were decreased. Conclusion: CSII intensive therapy brings excellent glycemic control and improves beta-cell function in type 2 diabetic patients with hyperglycemia.