干扰素栓配合CO_2激光治疗复发性重度宫颈糜烂

Application of Interferon and Carbon Dioxide Laser in the Treatment of Recurrent Severe Cervical Erosion

目的比较干扰素栓配合CO2激光与单纯CO2激光治疗复发性重度宫颈糜烂的疗效.方法2002年1月～2004年12月,随机将73例复发性重度宫颈糜烂患者随机分为干扰素栓配合CO2激光组(联合组,38例)与单纯CO2激光治疗组(对照组,35例).联合组在行激光烧灼前、后分别接受干扰素栓治疗6 d和12 d;对照组仅接受单纯激光治疗.结果联合组在术后阴道排液量、流血量、流血时间上优于对照组(P＜0.05).术后1、3月治愈率为92.1%和97.4%,优于对照组的80.0%和85.7%(P＜0.05).结论干扰素栓配合CO2激光治疗重度宫颈糜烂具有操作简便、起效迅速、无明显并发症的优点,且比单纯CO2激光治疗疗效更为确切.

Objective To comparatively analyze the carbon dioxide laser with or without interferon in the treatment of recurrent severe cervical erosion. Method Seventy three cases of recurrent severe cervical erosion were randomly divided into laser treatment group(control group, n=35) and laser with interferon treatment group(study group, n=38). Laser treatment was same in both group except interferon were administered for 6 and 12 days before and after laser treatment respectively in study group. Results Study group show a better result in terms of draining volume, bleeding volume and bleeding duration when compared with control group. The 1- and 3-months cure rate were 92.1% and 97.4% in study group versus 80.0% and 85.7% in control group (P<0.05). Conclusion Laser treatment associated with interferon administration demonstrates a more favorable result when compared with laser treatment alone for recurrent severe cervical erosion.