干扰素治疗慢性乙型病毒性肝炎疗效的影响因素分析

Factors Affecting the Response to Interferon Treatment of Patients with Chronic Hepatitis B

目的探讨α-干扰素(α-IFN)治疗慢性乙型病毒性肝炎(CHB)疗效的影响因素。方法根据治疗后HBVDNA和ALT水平,HBeAg是否转阴,将140例采用α-2bIFN治疗的CHB病人,分为应答组和无应答组。采用荧光PCR法定量检测HBVDNA,ELLSA法检测乙肝病毒(HBV)和丁肝病毒(HDV)标志物,x2检验分析IFN治疗CHB应答相关因素。结果应答组与无应答组间患者年龄和性别无统计学差异,但治疗前患者血清HBVDNA定量、ALT水平、HBeAg和是否重叠HDV感染有统计学差异。结论治疗前HBVDNA水平较低,ALT水平较高,HBeAg阳性和无重叠HDV感染的患者IFN治疗效果较好。

Objective To investigate the factors affecting the response to interferon treatment in patients with chronic hepatitis B. Methods 140 chronic hepatitis B patients received α-2b interferon treatment of 3.0 MU muscle injection 3 times a week (for patients 8-16 year old) or 5.0 MU muscle injection 3 times a week (for patients 17-56 year old) for 6 months. Patients were divided into response group or non-response group based on their HBV DNA level, and whether HBeAg turned negative and ALT returned normal or not. HBV DNA was quantified with fluorescence quantitative PCR. HBV and HDV markers in serum were tested with ELISA. Clinical data of these two groups before IFN therapy were analyzed. Results There are significant differences between the two groups in HBV DNA level, HBeAg positive rate, ALT level and superinfection with HDV. However, it is not correlated with age or gender. Conclusion a-2b IFN therapy in chronic hepatitis B showed better effects on patients with low level of HBV DNA, high level of ALT, HBeAg positive and no superinfection with HDV.