一起由H3N2病毒引起流感局部暴发的调查

The Research and Analysis A Local Epidemic of H3N2 Flu Virus

目的通过对湛江市某镇三间学校流感病例的流行病学、临床症状与体征、实验室检测结果等分析,进一步探索该次流感的流行因素,预测其流行趋势,指导控制措施。方法采用流行病学描述方法,对学校报告病例进行个案调查,入户调查镇城区附近村庄居民流感发生情况,调查该镇个体诊所近期收治流感病人情况,流感病例的家庭成员发病情况,采集病人咽拭子分离与鉴定病原体,采集病人急性期与恢复期血清检测流感抗体滴度。结果三间学校共发生367例流感病例,罹患率8.10%;采集22份病人咽拭子检测,流感抗原4份阳性,PCR检测4份阳性,病毒分离3份阳性并经鉴定均为H3N2型流感病毒。18例病人恢复期是急性期血清抗体滴度4倍以上增长的有14例。结论初步认为该镇三间学校出现流感局部暴发,病原体考虑为H3N2型流感病毒。

Objective To discuss further the epidemic causation, forecast the epidemic trend and put the control in practice, by the analyses of epidemiology,the clinic symptoms and the lab's examination of three high schools of some town of Zhanjiang city. Methods The epidemic characterization was adopted to carry out the individual investigate of the cases reported in school, research in house of the status of flu besides the town, the treat of these cases and family members' instance. Collect secretion of pharynx and identify the pathogeny of the patients, examine the antibody in the serums during the disease and recovery. Results 367 cases were discovered in those schools, about 8.10% of the members. 4 positive cases were found by pharynx secretion's examination of 22 patients,examined by PCR. 3 positive cases were examined in separation of virus identified H3N2 flu virus. Conclusion Local flu prevail were affirmed in three schools of the town and H3N2 flu virus was the suspicion.