肺炎衣原体感染与冠心病关系的Meta分析

Meta-analysis on the Relationship of Chlamydia Pneumonia Infection and Coronary Heart Disease

目的研究肺炎衣原体(CP)感染与冠心病(CHD)的关系。方法以CPIgG抗体为检测指标,全面收集有关CP感染与CHD关系的原始文献,根据抗体检测方法的不同将文献进行分类,采用ReviewManager4.2软件对各类文献进行Meta分析。结果共纳入原始文献29篇,Meta分析结果显示,全部文献、酶联免疫试验(ELISA)、金标免疫斑点法(DIGFA)和微量免疫荧光法(MIF)测定IgG抗体的OR值(95%CI)分别为4.00(3.07熏5.22)、2.86(1.89熏4.32)、14.89(1.46熏151.57)和4.46(3.15熏6.32)。结论CP感染与CHD之间存在相关关系,CP感染可能是CHD的危险因素之一。

Objective To determine the relationship of chlamydia pneumonia(CP)infection and coronary heart disease(CHD). Methods Studies published before 2004 that had reported on correlations between CHD and CP were collected. Studies were sorted into four sorts according to different testing methods. We determined to use either fixed effect model or random effect model according to the result of heterogeneity test. Meta-analysis was done by RevMan 4.2. Results Totally 29 studies were included into the review. The odd ratio(OR)to review all literature enzyme-linked immunosorbent assay(ELISA), dot-immunogdd filtration assay(DIGFA), and micro-immunofluorescence(MIF)was 4.00(3.07, 5.22), 2.86(1.89, 4.32), 14.89(1.46, 151.57), and 4.46(3.15, 6.32). Conclusion CP infection is associated with CHD, CP infection may be one of the risk factors of CHD.