少精子症患者血清和精浆性激素水平的测定及其意义

Detection of Sex Hormone in Serum and Semen of Patients with Idiopathic Oligospermia and Its Significance

通过测定少精子症患者血清和精浆睾酮(T)、游离睾酮(FT)和性激素结合球蛋白(SHBG)水平,比较分析血清、精浆T、FT、SHBG与少精子症的关系。对照组和少精子组男性于上午8:0010:00留取血标本,同时留取精液。精液常规分析判断精子密度,RIA测定血清、精浆T、FT、SHBG水平。少精子症患者血清T、FT、SHBG浓度分别为28.11±11.54nmol/L、94.88±42.04pmol/L、41.61±18.86nmol/L,与对照组30.03±13.07nmol/L、97.50±46.96pmol/L、40.37±16.73nmol/L相比,无显著性差异(P>0.05);少精子症患者精浆T浓度为1.60±1.09nmol/L,低于对照组1.99±1.18nmol/L,但无显著性差异(P>0.05);少精子症患者精浆FT浓度0.52±0.44pmol/L显著低于对照组2.01±0.32pmol/L(P<0.01);而少精子症患者精浆SHBG浓度0.22±0.15nmol/L,显著高于对照组0.17±0.21nmol/L(P<0.01)。精浆FT、SHBG的测定有利于少精症患者的早期诊断和治疗。

The objective of this study was to detect testosterone(T), free testosterone (FT) and sex hormone-binding globulin(SHBG) in serum and semen of patients with idiopathic oligospermia, and further analyze the relationship between T, FT, SHBG and idiopathic oligospermia. Blood and semen samples were collected from males of a normal control group and an idiopathic oligospermia group at 8:00-10:00 am. The sperm density in semen was detected by routine semen analysis, while T, FT, SHBG in serum and semen were detected by RIA. There were no significant differences in serum concentrations of T, FT, SHBG between normal control group \[(30.03±13.07)nmol/L,(97.50±46.96)pmol/L,(40.37±16.73)nmol/L, respectively\] and idiopathic oligspermia group \[(28.11±11.54)nmol/L,(94.88±42.04)pmol/L,(41.61± 18.86 )noml/L\](all P>0.05). There were significant differences in semsn concentrations of FT and SHBG between normal control group\[(2.01±0.32) pmol/L,(0.17±0.21)nmol/L\] and idiopathic oligspermia group \[(0.52±0.44) pmol/L,(0.22±0.15)nmol/L\](P<0.01). But the difference was not significant in the semen concentrations of T between the groups of normal control \ and idiopathic oligospermia(1.60±1.09nmol/L)(P>0.05). Therefore, measurement of semsn FT, SHBG concentration could early reflect the function of tesis, which is useful for early diagnosis and treatment of idiopathic oligospermia.