1,6二磷酸果糖联用纳络酮治疗婴幼儿重症肺炎并心力衰竭临床观察

To observe the curative effect of FDP and naloxone in treating the infants suffering severe pneumonia with heart failure

目的探讨1,6二磷酸果糖(FDP)联用纳络酮治疗婴幼儿重症肺炎并心力衰竭(简称肺炎心衰)的临床疗效。方法42例患儿随机分为两组,治疗组21例,对照组21例,除进行常规抗感染、西地兰强心、供氧、利尿、扩管外,治疗组于入院当天加用FDP0.2g·kg-1·d-1(30gtt/min)静脉滴注,每日1次,疗程3~5d,纳络酮0.02~0.04mg·kg-1·次-1,静脉注射,每日1~2次,疗程2~4d,入院时及治疗4d后抽血检测血清心肌酶CK、CK-MB,观察临床症状及体征,进行疗效评定。结果与对照组相比,治疗组显效率、总有效率明显提高,心肌酶CK、CK-MB明显降低,差异显著(P<0.05)。结论FDP联合纳络酮治疗肺炎心衰疗效显著,未发现不良反应。

Object To study the therapeutic effect of FDP(fructose 1,6 diphosphate) and Naloxone in infants suffering severe pneumonia with heart failure.Methods Fourty-two cases were divided into two groups at random,besides the routine treatment,the treatment group(21 cases) were treated with FDP (0.2g·kg^(-1)·d^(-1), iv drip 30gtt/min qd) and Naloxone (0.02-0.04mg/kg iv qd or bid) for 3-5d and 2-4d respectively.Investigating serum contents of the heart enzymes(CK,CK-MB) at the first day and four days later.Results In the treatment group, the obvious effective rate and the total effective rate were improved obviously and a significant decrease of the heart enzymes could be seen, the difference was significant between the two groups,P<0.05.Conclusion FDP and Naloxone are effective in treating pneumonia with heart failure and few side effects were found.