中国人载脂蛋白E基因多态性与脑梗死关系的Meta分析

Meta Analysis on Relationship between ApoE Polymorphism and Cerebral Infarction in Chinese Population

[目的]探讨我国人群载脂蛋白E(ApoE)基因多态性与脑梗死的相关性。[方法]通过文献检索收集脑梗死组和非脑梗死组的病例对照研究,剔除不符合要求的文献,在全面文献回顾的基础上对各研究OR值进行Meta分析。[结果]共有13篇符合条件的文献纳入分析,Meta分析结果表明,以野生型E3/3基因型为参照,携带E2/2,E3/2,E4/2,E4/3,E4/4基因型的个体发生脑梗死的危险性的OR值和95%可信区间分别为3.26(0.73～14.66)、1.26(0.90～1.75)、2.61(1.36～5.01)、2.49(1.86～3.35)和6.67(2.74,16.21),携带ε4的个体OR值和95%可信区间为2.77(2.11～3.63)。[结论]ε4携带者有发生脑梗死的倾向。

[Objective]To study the relationship between ApoE polymorphism and susceptibility of cerebral infarction in Chinese by Meta-analysis.[Methods]Related literatures with same topic and similar methods concerning Chinese population were reviewed; Meta-analysis was applied with a fixed effect model for the collected data. OR value in those studies were incorporated by Meta-analysis to assess susceptibility of cerebral infarction with ApoE polymorphism.[Results]13 papers were selected based on the criteria. Meta analysis results showed that the combined OR values(95%CI) of cerebral infarction for subjects of E2/2、E3/2、E4/2、E4/3、E4/4 were 3.26(0.73～14.66)、1.26(0.90～1.75)、2.61(1.36～5.01)、2.49(1.86～3.35)and 6.67(2.74,16.21)respectively. The combined OR values(95%CI) of cerebral infarction for ε4 carriers was 2.77(2.11～ 3.63).[Conclusions]The results suggested that ApoE polymorphism was significantly associated with susceptibility of cerebral infarction. ε4 carriers had higher risk suffering from cerebral infarction than others.