摘要
目的探讨153Sm-乙二胺四亚甲基膦酸(EDTMP)治疗癌性骨痛疗效的影响因素。方法对110例首次应用153Sm-EDTMP治疗的恶性肿瘤骨转移疼痛患者,根据治疗效果,分别按患者的年龄、疼痛程度、原发癌类型、骨转移灶数目、主要疼痛部位进行分组疗效与统计检验。结果110例患者首次治疗后疼痛缓解的总有效率为73.64%。乳腺癌和前列腺癌疗效明显好于肺癌、鼻咽癌、消化道癌(χ2=19.959,P<0.005);中腰或腰背痛者疼痛缓解有效率明显高于腰骶、髋关节伴下肢痛者(χ2=21.96,P<0.005);轻度疼痛缓解的有效率明显高于酷痛(χ2=13.359,P<0.005)。而患者年龄、骨转移数目对疗效的影响不显著。结论原发癌为乳腺癌、前列腺癌伴骨转移者、疼痛主要以腰痛或腰痛伴其他部位疼痛及轻度疼痛者行153Sm-EDTMP治疗疗效更佳。
Objective To seek for correletive influencing factors of treating effect for metastasized bone pain by ^(153)Sm-EDTMP. Methods 110 cases with bone metastasis and pain were treatnent with ^(153)Sm-EDTMP.The effects were analyzed and according to grouping separately of age,the degree of pain,the kinds of primary cancers,the amount of metastasis,the prime site of pain.Results The total effective ratio of pain relief was 73.64%.The curative effect of breast cancer and prostate cancer was better than lung caner,nasopharyngeal darcinoma,alimentary canal cancer(χ~2=19.959,P<0.005);the effective ratio of pain relaxation of mid-loins and back exceedes that of sacrum, coxae joint companied with lower limbs ache(χ~2=21.96,P<0.005 );the relief effective ratio of pain was higher than ostealgia(χ~2=13.395,P<0.005 ).However,the efficacy was not influenced by the age and sum of bone metastasis.Conclusion The treatment with ^(153)Sm-EDTMP have a batter effect in patientd with breast cancer,prostate cancer,lumbago or lumboge accompanief with metastasis lighter pain.
出处
《宁夏医学杂志》
CAS
2005年第7期456-458,共3页
Ningxia Medical Journal
