青蒿琥酯与吡喹酮联用对日本血吸虫不同感染度家兔的治疗效果

EFFECT OF COMBINED THERAPY OF ARTESUNATE AND PRAZIQUANTEL FOR DIFFERENT INFECTIONSITY OF SCHISTOSOMA JAPONICUM IN RABBITS

目的探讨青蒿琥酯和吡喹酮联用对日本血吸虫不同感染度家兔的治疗效果。方法实验分两次进行。实验一30只家兔分6组,第1、2、3组分别感染200、500、800条尾蚴,7d后灌服青蒿琥酯和吡喹酮;第4、5、6组亦分别感染200、500、800条尾蚴,为不服药对照组。实验二15只家兔分3组,每兔均感染血吸虫尾蚴800条。第1组为青蒿琥酯和吡喹酮联合用药组,第2组为单用青蒿琥酯组,第3组为不服药对照组。结果实验一服药组200条尾蚴感染组的减虫率和减雌率分别为96.28%和97.31%,800条感染组的减虫率和减雌率分别为72.64%和75.28%,两组比较差异有显著性(P<0.05)。实验二联合用药组的减虫率和减雌率分别为93.25%和95.14%,单用青蒿琥酯组的减虫率为82.72%和84.07%,两组比较差异有显著性(P<0.05)。结论联合应用青蒿琥酯和吡喹酮对轻感染兔的疗效优于重感染兔,在感染度相同的情况下,联合用药组的疗效优于单用青蒿琥酯组。

Objective To explore the effect of combined therapy of artesunate and praziquantel for different infectiosity of Schistosoma japonicum in rabbits. Methods In the first experiment, the 30 rabbits were divided into 6 groups, the rabbits in group 1, 2 and 3 were infected with 200, 500 and 800 Schistosoma cercariae each, respectively, and treated with artesunate and praziquantel; and the rabbits in group 4, 5 and 6 infected with 200, 500 and 800 cercariae each were not treated. In the second experiment, all the rabbits were infected with 800 cercariae each and then divided into 3 groups: Group 1, the rabbits were treated with artesunate and praziquantel; Group 2, treated with artesunate alone; Group 3, without treatment. Results In the first experiment, the worm reduction rate and female reduction rate were 96.28% and 97.31% in Group 1, which were higher than those in Group 3 (72.64% and 75.28%). The differences were statistically significant (P<0.05). In the second experiment, the worm reduction rate and female reduction rate were 93.25% and 95.14% in Group 1, which were higher than those in Group 2 (82.72% and 84.07%) (P<0.05). Conclusion The effect of combined therapy of artesunate and praziquantel is better in light S. japonicum infection than in heavy infection. In the same infectiosity, the effect of the combined therapy of artesunate and praziquantel is better than that of artesunate alone.