减少毒性和不良反应的免疫抑制策略研究进展

Research progress of minimizing the side effects of immunosuppression in renal transplant recipients

新型、高效免疫抑制剂的临床应用使肾移植术后急性排斥反应的发生率明显降低。然而,免疫抑制剂的毒性作用对肾移植患者的人/肾长期存活率却产生明显影响,正日益受到人们的重视。作者对目前减少毒性和不良反应的免疫抑制方案进行综述。

The availability of potent new immunosuppressive drugs has led to a dramatic reduced in the incidence of early episodes of acute rejection in kidney transplant recipients. However,toxicities of currently available immunosuppressants ironically may influence long-term allograft and patient outcomes.Recent clinical experience with immunosuppression protocols designed tominimize these long-term toxicities by reducing or eliminating doses of calcineurin inhibitors(CNI) or corticosteroids was reviewed.