期刊文献+

阿尔茨海默病动物模型的概况(综述) 被引量:8

下载PDF
导出
摘要 阿尔茨海默病(AlzheimerDisease,AD)是一种进行性神经退行性疾病,关于AD的病因有多种学说,并依据其病因建立了多种动物模型。该文就目前各种动物模型及其优缺点作一综述。
出处 《中国神经免疫学和神经病学杂志》 CAS 2005年第4期223-225,共3页 Chinese Journal of Neuroimmunology and Neurology
基金 北京市自然科学基金资助项目(503216) 卫生部北京医院博士后启动基金资助项目(20010303)
  • 相关文献

参考文献15

  • 1Kuo H, Ingram DK, Walker LC, et al. Similarities in the age-related hippocampal deposition of periodic acidschiff-positive granules in the senescence-accelerated mouse P8 and C57BL/6 mouse strains[J]. Neuroscience, 1996,74:733-40.
  • 2魏小龙,张永祥.老年性痴呆动物模型研究进展[J].中国药理学通报,2000,16(4):372-376. 被引量:27
  • 3Hefti F, Dravid A, Hartikka J. Chronic intraventricular injections of NGF elevate hippocampal choline acetyltransferase activity in adult rats with septohippocampal lesions[J]. Brain Res, 1984,293:305-311.
  • 4Miyamoto M, Koto J, Narumi S, et al. Lesions of the rat basal forebrain leads to memory impairments in passive and active avoidance tasks[J]. Brain Res, 1985,328:97-104.
  • 5Sofroniew MV, Pearson RCA. Degeneration of cholinergic neurons in the basal nucleus following kainic or N-methyl-D-aspartic acid application to the cerebral cortex in the rat[J]. Brain Res, 1985,339:186-190.
  • 6Fisher A, Hanin I. Potential animal models for senile dementia of Alzheimer's type, with emphasis on AF64A-induced cholinotoxicity[J]. Annu Rev Pharmacol Toxicol, 1986,26:161-181.
  • 7Nabeshima T. Trial to produce animal model of Alzheimer's disesse by continuous infusion of beta-amyloid protein into the rat cerebral ventricle[J]. Nihon Shinkei Seishin Yakurigaku Zasshi, 1995,15:411-418.
  • 8Alvarez XA, Miguel-Hidnlgo JJ, Fernandez-Novoa L, et al. Introhippocampal injections of the beta-amyloid 1-28 fragment induces behavioral deficits in rats[J]. Methods Find Exp Clin Pharmacol, 1997,19(7):471-479.
  • 9Florence AL, Gauthier A, Ponsar C, et al. An experimental animal model of aluminium overload[J]. Neurodegeneration, 1994,3:315-323.
  • 10罗焕敏,肖飞.D-半乳糖和三氯化铝诱导小鼠产生类阿尔茨海默病变[J].中国药理学与毒理学杂志,2004,18(1):22-26. 被引量:49

二级参考文献9

共引文献131

同被引文献110

引证文献8

二级引证文献30

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部