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PD98059提高HBx^+HepG2对顺铂的敏感性 被引量:2

The sensitivity improvement of HBx+HepG2 to CDDP with PD98059
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摘要 细胞外信号调节激酶(ERK)级联是丝裂原活化蛋白激酶(MAPK)通路中的重要一员,与细胞增殖、分化、凋亡关系密切[1].乙型肝炎病毒(HBV)x(HBx)基因是一种致肝癌的重要因子,能激活肝细胞内ERK通路,从而影响细胞生物学特性[2,3].本实验通过稳定表达HBx的HepG2细胞(HBx+HepG2)对顺铂以及顺铂联合MAPK/ERK激酶(MEK)特异性抑制剂PD98059敏感性差异的研究,探讨PD98059提高HBx+HepG2对顺铂敏感性的作用机制.
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2005年第7期543-544,共2页 Chinese Journal of Hepatology
关键词 PD98059 HBx^+HepG2 肝炎病毒 肝细胞 顺铂 敏感性 引物设计 Carcinoma, hepatocellular Hepatitis B virus Cisplatin
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参考文献6

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共引文献16

同被引文献17

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