摘要
目的检测心房颤动(AF)患者血浆组织因子(TF)和组织因子途径抑制物(TFPI)抗原的变化,探讨组织因子凝血途径在心房血栓形成机制中的作用。方法选择心房颤动患者64例,采用酶联免疫吸附(ELISA)方法测定血浆TF和TFPI抗原水平,并与对照组进行比较。结果①与正常对照组比较,AF组血浆TF抗原水平显著增高[(1060.0±669.8)pg/mLvs(423.6±245.1)pg/mL,P=0.000],总TFPI和游离TFPI抗原水平降低[(38.2±8.9)ng/mLvs(70.1±24.0)ng/mL,P=0.000;(26.3±8.0)ng/mLvs(41.2±16.7)ng/mL,P=0.000]。②伴左房血栓心房颤动组与无左房血栓心房颤动组比较,伴左房血栓心房颤动组TF抗原水平显著增高[(1431.4±564.5)pg/mLvs(904.6±660.3)pg/mL,P=0.004],总TFPI和游离TFPI抗原水平降低[(33.1±9.6)ng/mLvs(40.0±7.8)ng/mL,P=0.01;(22.9±8.2)ng/mLvs(22.7±7.4)ng/mL,P=0.048]。结论心房颤动患者血浆组织因子途径改变表现为凝血活性增高和抗凝活性减低,组织因子凝血途径参与了心房颤动患者心房血栓形成机制。
Purpose To investigate the relationship between the tissue factor coagulation pathway and the mechanisms of atrial thrombosis in patients with atrial fibrillation (AF) by measuring the plasma levels of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) antigens. Methods Sixty-four patients with AF were enrolled,the plasma levels of TF and TFPI antigen were measured by ELISA method.The results of patients with atrial fibrillation were compared with the normal control's,and the comparison was also done between the patients with atrial thrombus and no-thrombus. Results The plasma levels of TF antigen in patients with atrial fibrillation were significantly higher than the normal control [(1 060.0±669.8) pg/mL vs (432.6±245.1) pg/mL,P=0.000];the plasma levels of total TFPI antigen were lo- wer than normal control [ (38.2±8.9)ng/mL vs (70.0±24.0)ng/mL,P=0.000].The plasma levels of TF antigen in patients with atrial thrombus were higher than the patients with no-thrombus [(1 431.4± 564.5)pg/mL vs (904.6±660.3) pg/mL,P=0.004],the plasma levels of total TFPI antigen with thrombus were lower than the patients with no-thrombus [(33.1±9.6) ng/mL vs (40.0±7.8) ng/mL,P= 0.01]. Conclusions The changes of tissue factor coagulation pathway were involving in the mechanisms of atrial thrombosis in patients with atrial fibrillation.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2005年第4期451-454,共4页
Fudan University Journal of Medical Sciences
基金
上海市科委科研计划资助(034119913)
