慢性光线性皮炎紫外线作用光谱的研究

The Action Spectrum of Ultraviolet Light in Chronic Actinic Dermatitis

目的测定慢性光线性皮炎(CAD)紫外线作用光谱。方法以SUV1000型日光紫外模拟器为光源,测定131例疑诊和13例已确诊CAD患者的长波紫外线(UVA)和中波紫外线(UVB)最小红斑量(MED)。结果131例患者中,85例确诊为CAD。85例患者中89.41%UVA-MED降低,范围1-20 J/ cm2;69.41%UVB-MED降低,范围2.8-20mJ/cm2;30.58%单一UVA-MED下降,10.59%单一UVB-MED 下降。13例以前已经确诊为CAD的患者,重新测定MED发现,3例发病时MED在正常范围,9例作用光谱发生了改变。结论LVA在CAD作用光谱中占有重要地位CAD的作用光谱具有波动性,光敏感性增强可从一个波段变化至另一波段。

Objective To study the action spectrum of ultraviolet light in chronic actinic dermatitis (CAD). Methods The minimal erythema doses (MEDs) of ultraviolet A (LVA) and ultraviolet B (UVB) were measured, by application of SUV1000 type ultraviolet simulator, in 131 presumptive cases of CAD and 13 cases previously diagnosed CAD. Results Eighty-five of 131 cases were diagnosed as CAD by a lower UVA-MED and/or UVB-MED. A lower UVA-MED was found in 89.41% of the 85 cases, ranging from 1 J/cm2 to 20 J/cm2, while a lower UVB-MED in 69.41%, ranging from 2.8 mJ/cm2 to 20 mJ/cm2. Out of 85 cases, 30.58% were found to be sensitive to UVA alone, and 10.59% to UVB alone. Out of the 13 cases previously diagnosed as CAD, 3 showed normal MED for both UVA and LVB at the onset, and 9 showed that the UVA/ UVB action spectrums were changed. Conclusions UVA plays an important role in the action spectrum in CAD. The action spectrum of CAD can be changed from UVA to UVB and vice versa.