乳腺神经内分泌癌5例临床病理分析

Clinical and Pathological Analysis of 5 Cases of Breast Neuroedocrine Carcinomas (NEC)

目的:探讨乳腺神经内分泌癌的临床病理特点。方法:从525例乳腺癌手术标本中,经光镜观察病理形态及免疫组化测定神经内分泌标志物筛选出5例神经内分泌癌及6例导管癌向神经内分泌细胞分化进行分析。结果:患者年龄平均41岁,肿瘤最大径平均2.8cm,均无淋巴结转移,临床分期限于Ⅱ期内,均施行乳腺根治术或改良根治术,5例均为分别阳性表达>50%,CGA、NSE、SYN2～3项不等,术后随访6月～34月,均无瘤存活。结论:本组乳腺神经内分泌癌患者年龄低于国外,发病率低于2%,预后优于其他类型乳腺癌。

Objective: To explore clinical and pathological features of breast NEC. Methods: From the operative specimens of 525 cases with breast carcinoma, according to morphological features by microscopic observation and detection of neuroendocrine markers by immunohistochemical staining, five cases of neuroendocrine carcinomas and six cases of ductal carcinomas with neuroendocrine cell differentiation were chosen and analysed. Results: The mean age of patients was 41 years. The mean size of tumors was 2.8cm. No metastases of lymph node were found and clinical stagings were below Ⅱ. Radical or modified radical resection of breast carcincmas were performed, CGA?NSE and SYN were positively expressed (at least 2/3) in all 5 cases. The positive rates of all tumor cells were >50%, Follow-up from 6 to 34 months were performed postoperatively, and all were tumor-free survivals. Conclusion: The age of the patients with breast NEC in China is lower compared to foreign countries. The incidence in this group is within 2% and the prognosis is superior to other types of breast carcinoma.